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High-intensity irreversible electroporation targeting intracellular structures enhance tumor ablation in lung cancer models

Fig 4

Impact of variable IRE parameters on mitochondrial dysfunction and oxidative stress.

(1) Mitochondrial membrane potential (MMP). (2) H2O2 production. (3) NO production. Data is represented as mean ± SEM (n = 3). Multiple-group comparisons were analyzed using one-way ANOVA followed by Tukey’s HSD post hoc test, with statistical significance indicated as: ###p < 0.001; N.S, not significant. Two-group tests were analyzed using unpaired two-tailed t-tests, with significance indicated as: *p < 0.05, **p < 0.01, ***p < 0.001.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0346472.g004