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6-Methoxyflavanones as Bitter Taste Receptor Blockers for hTAS2R39

Figure 4

Inhibition of response of 200 μM ECG (---) on hTAS2R39 (induced (•), non-induced (○)) by 4′-fluoro-6-methoxyflavanone (6) after simultaneous addition (n = 5) (A) and stepwise addition (n = 4) (B), by 6,3′-dimethoxyflavanone (3) after simultaneous addition (n = 4) (C) and stepwise addition (n = 3) (D), and by 6-methoxyflavanone (11) after simultaneous addition (n = 5) (E) and stepwise addition (n = 3) (F).

Data are presented as mean ±SEM of n separate experiments conducted in duplicate.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0094451.g004