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Open Access
Peer-reviewed
Research Article
Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease
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Emily Baker,
Roles Formal analysis, Methodology, Writing – original draft, Writing – review & editing
Affiliations Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom, UK Dementia Research Institute at Cardiff University, Cardiff, United Kingdom
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Rebecca Sims,
Roles Data curation, Writing – review & editing
Affiliation Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom
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Ganna Leonenko,
Roles Data curation, Writing – review & editing
Affiliation Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom
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Aura Frizzati,
Roles Data curation, Writing – review & editing
Affiliation Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom
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Janet C. Harwood,
Roles Writing – review & editing
Affiliation Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom
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Detelina Grozeva,
Roles Data curation, Writing – review & editing
Affiliation Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom
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GERAD/PERADES ,
¶For more information on these consortia and their full membership lists, please see the Acknowledgments and
⨯S1 Appendix . -
CHARGE ,
¶For more information on these consortia and their full membership lists, please see the Acknowledgments and
⨯S1 Appendix . -
ADGC ,
¶For more information on these consortia and their full membership lists, please see the Acknowledgments and
⨯S1 Appendix . -
EADI ,
¶For more information on these consortia and their full membership lists, please see the Acknowledgments and
⨯S1 Appendix . -
IGAP consortia ,
¶For more information on these consortia and their full membership lists, please see the Acknowledgments and
⨯S1 Appendix . -
Kevin Morgan,
Roles Data curation, Writing – review & editing
Affiliation Human Genetics, School of Life Sciences, Life Sciences Building A27, University Park, University of Nottingham, Nottingham, NG7 2RD, United Kingdom
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Peter Passmore,
Roles Data curation, Writing – review & editing
Affiliation Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queens University, Belfast, United Kingdom
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Clive Holmes,
Roles Data curation, Writing – review & editing
Affiliation Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, United Kingdom
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John Powell,
Roles Data curation, Writing – review & editing
Affiliations Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, United Kingdom, Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
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Carol Brayne,
Roles Data curation, Writing – review & editing
Affiliation Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
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Michael Gill,
Roles Data curation, Writing – review & editing
Affiliations Mercer’s Institute for Research on Ageing, St. James’ Hospital, Dublin, Ireland, James Hospital and Trinity College, Dublin, Ireland
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Simon Mead,
Roles Data curation, Writing – review & editing
Affiliation MRC Prion Unit at UCL, Institute of Prion Diseases, London, United Kingdom
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Paola Bossù,
Roles Data curation, Writing – review & editing
Affiliation Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Rome, Italy
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Gianfranco Spalletta,
Roles Data curation, Writing – review & editing
Affiliation Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy
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Alison M. Goate,
Roles Data curation, Writing – review & editing
Affiliations Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St Louis, Missouri, United States of America
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Carlos Cruchaga,
Roles Data curation, Writing – review & editing
Affiliations Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America, Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St Louis, Missouri, United States of America
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Wolfgang Maier,
Roles Data curation, Writing – review & editing
Affiliation German Centre for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany
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Reinhard Heun,
Roles Data curation, Writing – review & editing
Affiliation Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany
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Frank Jessen,
Roles Data curation, Writing – review & editing
Affiliations German Centre for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany, Department of Psychiatry and Psychotherapy, University of Cologne, 50937 Cologne, Germany
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Oliver Peters,
Roles Data curation, Writing – review & editing
Affiliations Department of Psychiatry and Psychotherapy, Charité Berlin, Berlin, Germany, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
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Martin Dichgans,
Roles Data curation, Writing – review & editing
Affiliations Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany, German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, 80336, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
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Lutz FröLich,
Roles Data curation, Writing – review & editing
Affiliation Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
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Alfredo Ramirez,
Roles Data curation, Writing – review & editing
Affiliations Department of Psychiatry and Psychotherapy, University of Cologne, 50937 Cologne, Germany, Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
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Lesley Jones,
Roles Data curation, Writing – review & editing
Affiliation Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom
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John Hardy,
Roles Data curation, Writing – review & editing
Affiliation Department of Molecular Neuroscience, UCL, Institute of Neurology, London, United Kingdom
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Dobril Ivanov,
Roles Data curation, Writing – review & editing
Affiliation UK Dementia Research Institute at Cardiff University, Cardiff, United Kingdom
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Matthew Hill,
Roles Data curation, Writing – review & editing
Affiliation UK Dementia Research Institute at Cardiff University, Cardiff, United Kingdom
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Peter Holmans,
Roles Data curation, Writing – review & editing
Affiliation Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom
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Nicholas D. Allen,
Roles Data curation, Writing – review & editing
Affiliation UK Dementia Research Institute at Cardiff University, Cardiff, United Kingdom
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B. Paul Morgan,
Roles Data curation, Writing – review & editing
Affiliation UK Dementia Research Institute at Cardiff University, Cardiff, United Kingdom
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Sudha Seshadri,
Roles Data curation, Writing – review & editing
Affiliation Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
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Gerard D. Schellenberg,
Roles Data curation, Writing – review & editing
Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
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Philippe Amouyel,
Roles Data curation, Writing – review & editing
Affiliation Univ. Lille, Inserm, CHU Lille University Hospital, Institut Pasteur de Lille, LabEx DISTALZ-UMR1167 - RID-AGE - Risk factors and molecular determinants of aging-related, F-59000 Lille, France
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Julie Williams ,
Roles Data curation, Funding acquisition, Supervision, Writing – review & editing
* E-mail: WilliamsJ@cardiff.ac.uk (JW); EscottPriceV@cardiff.ac.uk (VEP)
Affiliations Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom, UK Dementia Research Institute at Cardiff University, Cardiff, United Kingdom
⨯ - [ ... ],
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Valentina Escott-Price
Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing
* E-mail: WilliamsJ@cardiff.ac.uk (JW); EscottPriceV@cardiff.ac.uk (VEP)
Affiliations Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom, UK Dementia Research Institute at Cardiff University, Cardiff, United Kingdom
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Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease
- Emily Baker,
- Rebecca Sims,
- Ganna Leonenko,
- Aura Frizzati,
- Janet C. Harwood,
- Detelina Grozeva,
- GERAD/PERADES,
- CHARGE,
- ADGC,
- EADI
- Published: July 8, 2019
- https://doi.org/10.1371/journal.pone.0218111
- See the preprint