Side-by-side comparison of published small molecule inhibitors against thapsigargin-induced store-operated Ca2+ entry in HEK293 cells

Katherine Norman; Karen E. Hemmings; Heba Shawer; Hollie L. Appleby; Alan J. Burnett; Nurasyikin Hamzah; Rajendra Gosain; Emily M. Woodhouse; David J. Beech; Richard Foster; Marc A. Bailey

doi:10.1371/journal.pone.0296065

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Open Access

Peer-reviewed

Research Article

Side-by-side comparison of published small molecule inhibitors against thapsigargin-induced store-operated Ca²⁺ entry in HEK293 cells

Katherine Norman,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations School of Chemistry, University of Leeds, Leeds, West Yorkshire, United Kingdom, Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom

https://orcid.org/0000-0003-3038-8846

⨯
Karen E. Hemmings,

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom

https://orcid.org/0000-0002-4967-6314

⨯
Heba Shawer,

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom

https://orcid.org/0000-0003-1813-427X

⨯
Hollie L. Appleby,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯
Alan J. Burnett,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯
Nurasyikin Hamzah,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation School of Chemistry, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯
Rajendra Gosain,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯
Emily M. Woodhouse,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯
David J. Beech,

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯
Richard Foster,

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations School of Chemistry, University of Leeds, Leeds, West Yorkshire, United Kingdom, Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯
Marc A. Bailey

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: m.a.bailey@leeds.ac.uk

Affiliation Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯

Side-by-side comparison of published small molecule inhibitors against thapsigargin-induced store-operated Ca²⁺ entry in HEK293 cells

Katherine Norman,
Karen E. Hemmings,
Heba Shawer,
Hollie L. Appleby,
Alan J. Burnett,
Nurasyikin Hamzah,
Rajendra Gosain,
Emily M. Woodhouse,
David J. Beech,
Richard Foster

Published: January 23, 2024
https://doi.org/10.1371/journal.pone.0296065

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