ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial

Christos Rossios; Tufail Bashir; Marcus Achison; Simon Adamson; Asangaedem Akpan; Terry Aspray; Alison Avenell; Margaret M. Band; Louise A. Burton; Vera Cvoro; Peter T. Donnan; Gordon W. Duncan; Jacob George; Adam L. Gordon; Celia L. Gregson; Adrian Hapca; Cheryl Hume; Thomas A. Jackson; Simon Kerr; Alixe Kilgour; Tahir Masud; Andrew McKenzie; Emma McKenzie; Harnish Patel; Kristina Pilvinyte; Helen C. Roberts; Avan A. Sayer; Karen T. Smith; Roy L. Soiza; Claire J. Steves; Allan D. Struthers; Divya Tiwari; Julie Whitney; Miles D. Witham; Paul R. Kemp

doi:10.1371/journal.pone.0292402

Loading metrics

Open Access

Peer-reviewed

Research Article

ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial

Christos Rossios,

Roles Investigation, Writing – review & editing

Affiliation Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom

https://orcid.org/0000-0003-3470-3233

⨯
Tufail Bashir,

Roles Investigation, Writing – review & editing

Affiliation Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom
⨯
Marcus Achison,

Roles Data curation, Funding acquisition, Investigation, Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom
⨯
Simon Adamson,

Roles Data curation, Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom
⨯
Asangaedem Akpan,

Roles Investigation, Writing – review & editing

Affiliation University of Liverpool, Liverpool University Hospitals NHS FT Trust, Clinical Research Network Northwest Coast, Liverpool, United Kingdom
⨯
Terry Aspray,

Roles Investigation, Writing – review & editing

Affiliation AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational Clinical Research Institute, Newcastle University, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom
⨯
Alison Avenell,

Roles Investigation, Writing – review & editing

Affiliation Health Services Research Unit, University of Aberdeen, Aberdeen, United Kingdom
⨯
Margaret M. Band,

Roles Project administration, Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom
⨯
Louise A. Burton,

Roles Investigation, Writing – review & editing

Affiliations Medicine for the Elderly, NHS Tayside, Dundee, United Kingdom, Ageing and Health, University of Dundee, Dundee, United Kingdom
⨯
Vera Cvoro,

Roles Investigation, Writing – review & editing

Affiliations Victoria Hospital, Kirkcaldy, United Kingdom, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Peter T. Donnan,

Roles Data curation, Writing – review & editing

Affiliation Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, United Kingdom
⨯
Gordon W. Duncan,

Roles Investigation, Writing – review & editing

Affiliations Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, Medicine for the Elderly, NHS Lothian, Edinburgh, United Kingdom
⨯
Jacob George,

Roles Data curation, Writing – review & editing

Affiliation Dept Clinical Pharmacology, Division of Molecular & Clinical Medicine, University of Dundee Medical School, Ninewells Hospital, Dundee, United Kingdom
⨯
Adam L. Gordon,

Roles Investigation, Writing – review & editing

Affiliations Unit of Injury, Inflammation and Recovery, School of Medicine, University of Nottingham, Nottingham, United Kingdom, NIHR Nottingham Biomedical Research Centre, Department of Medicine for the Elderly, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom
⨯
Celia L. Gregson,

Roles Investigation, Writing – review & editing

Affiliations Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom, Older Person’s Unit, Royal United Hospital NHS Foundation Trust Bath, Bath, United Kingdom

https://orcid.org/0000-0001-6414-0529

⨯
Adrian Hapca,

Roles Data curation, Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom
⨯
Cheryl Hume,

Roles Project administration, Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom
⨯
Thomas A. Jackson,

Roles Investigation, Writing – review & editing

Affiliation Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom
⨯
Simon Kerr,

Roles Investigation, Writing – review & editing

Affiliation Department of Older People’s Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
⨯
Alixe Kilgour,

Roles Investigation, Writing – review & editing

Affiliations Medicine for the Elderly, NHS Lothian, Edinburgh, United Kingdom, Ageing and Health Research Group, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom

https://orcid.org/0000-0003-1270-821X

⨯
Tahir Masud,

Roles Investigation, Writing – review & editing

Affiliation Clinical Gerontology Research Unit, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, United Kingdom
⨯
Andrew McKenzie,

Roles Data curation, Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom
⨯
Emma McKenzie,

Roles Data curation, Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom
⨯
Harnish Patel,

Roles Investigation, Writing – review & editing

Affiliation NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHSFT, Southampton, Hampshire, United Kingdom

https://orcid.org/0000-0002-0081-1802

⨯
Kristina Pilvinyte,

Roles Project administration, Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom
⨯
Helen C. Roberts,

Roles Investigation, Writing – review & editing

Affiliation Academic Geriatric Medicine, University of Southampton, Mailpoint 807 Southampton General Hospital, Southampton, United Kingdom
⨯
Avan A. Sayer,

Roles Investigation, Writing – review & editing

Affiliation AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational Clinical Research Institute, Newcastle University, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom
⨯
Karen T. Smith,

Roles Project administration, Writing – review & editing

Affiliation Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom
⨯
Roy L. Soiza,

Roles Investigation, Writing – review & editing

Affiliation Ageing & Clinical Experimental Research (ACER) Group, University of Aberdeen, Aberdeen, United Kingdom

https://orcid.org/0000-0002-1397-4272

⨯
Claire J. Steves,

Roles Investigation, Writing – review & editing

Affiliation Department of Twin Research and Genetic Epidemiology, King’s College London & Department of Clinical Gerontology, King’s College Hospital, London, United Kingdom
⨯
Allan D. Struthers,

Roles Investigation, Writing – review & editing

Affiliation Dept Clinical Pharmacology, Division of Molecular & Clinical Medicine, University of Dundee Medical School, Ninewells Hospital, Dundee, United Kingdom
⨯
Divya Tiwari,

Roles Investigation, Writing – review & editing

Affiliation Bournemouth University and Royal Bournemouth Hospital, Bournemouth, United Kingdom
⨯
Julie Whitney,

Roles Investigation, Writing – review & editing

Affiliation School of Population Health & Environmental Sciences, King’s College London and King’s College Hospital, London, United Kingdom
⨯
Miles D. Witham,

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Writing – review & editing

Affiliation AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational Clinical Research Institute, Newcastle University, Cumbria Northumberland Tyne and Wear NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom
⨯
[ ... ],
Paul R. Kemp

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: p.kemp@imperial.ac.uk

Affiliation Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, United Kingdom

https://orcid.org/0000-0001-8975-7293

⨯
[ view all ]
[ view less ]

ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial

Christos Rossios,
Tufail Bashir,
Marcus Achison,
Simon Adamson,
Asangaedem Akpan,
Terry Aspray,
Alison Avenell,
Margaret M. Band,
Louise A. Burton,
Vera Cvoro

Published: October 20, 2023
https://doi.org/10.1371/journal.pone.0292402

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Fast-twitch muscle fibers
Is the Subject Area "Fast-twitch muscle fibers" applicable to this article?

Thanks for your feedback.
Slow-twitch muscle fibers
Is the Subject Area "Slow-twitch muscle fibers" applicable to this article?

Thanks for your feedback.
ACE inhibitor therapy
Is the Subject Area "ACE inhibitor therapy" applicable to this article?

Thanks for your feedback.
Body limbs
Is the Subject Area "Body limbs" applicable to this article?

Thanks for your feedback.
Sarcopenia
Is the Subject Area "Sarcopenia" applicable to this article?

Thanks for your feedback.
Strength training
Is the Subject Area "Strength training" applicable to this article?

Thanks for your feedback.
Leucine
Is the Subject Area "Leucine" applicable to this article?

Thanks for your feedback.
Variant genotypes
Is the Subject Area "Variant genotypes" applicable to this article?

Thanks for your feedback.