Fucosylated haptoglobin is a novel predictive marker of hepatocellular carcinoma after hepatitis C virus elimination in patients with advanced liver fibrosis

Kumiko Shirai; Hayato Hikita; Ryotaro Sakamori; Akira Doi; Yuki Tahata; Sadatsugu Sakane; Yoshihiro Kamada; Kazuhiro Murai; Akira Nishio; Ryoko Yamada; Takahiro Kodama; Yasutoshi Nozaki; Naruyasu Kakita; Hisashi Ishida; Fumihiko Nakanishi; Naoki Morishita; Kazuho Imanaka; Mitsuru Sakakibara; Tomohide Tatsumi; Eiji Miyoshi; Tetsuo Takehara

doi:10.1371/journal.pone.0279416

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Peer-reviewed

Research Article

Fucosylated haptoglobin is a novel predictive marker of hepatocellular carcinoma after hepatitis C virus elimination in patients with advanced liver fibrosis

Kumiko Shirai,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
⨯
Hayato Hikita,

Roles Conceptualization, Data curation, Project administration, Writing – original draft, Writing – review & editing

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
⨯
Ryotaro Sakamori,

Roles Data curation, Resources

Affiliations Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan, National Hospital Organization Osaka National Hospital, Osaka, Japan

https://orcid.org/0000-0002-1580-607X

⨯
Akira Doi,

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
⨯
Yuki Tahata,

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
⨯
Sadatsugu Sakane,

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
⨯
Yoshihiro Kamada,

Roles Investigation, Project administration, Writing – review & editing

Affiliation Division of Health Sciences, Department of Advanced Metabolic Hepatology, Osaka University Graduate School of Medicine, Suita, Japan

https://orcid.org/0000-0001-5485-902X

⨯
Kazuhiro Murai,

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan

https://orcid.org/0000-0001-8634-2922

⨯
Akira Nishio,

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
⨯
Ryoko Yamada,

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
⨯
Takahiro Kodama,

Roles Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
⨯
Yasutoshi Nozaki,

Roles Data curation, Resources

Affiliation Kansai Rosai Hospital, Amagasaki, Japan
⨯
Naruyasu Kakita,

Roles Data curation, Resources

Affiliation Kaizuka City Hospital, Kaizuka, Japan
⨯
Hisashi Ishida,

Roles Data curation, Resources

Affiliation Ikeda City Hospital, Ikeda, Japan
⨯
Fumihiko Nakanishi,

Roles Data curation, Resources

Affiliation National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Japan
⨯
Naoki Morishita,

Roles Data curation, Resources

Affiliation Minoh City Hospital, Minoh, Japan
⨯
Kazuho Imanaka,

Roles Data curation, Resources

Affiliation Itami City Hospital, Itami, Japan
⨯
Mitsuru Sakakibara,

Roles Data curation, Resources

Affiliation Yao Municipal Hospital, Yao, Japan
⨯
Tomohide Tatsumi,

Roles Conceptualization, Data curation, Resources

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
⨯
Eiji Miyoshi,

Roles Conceptualization, Writing – review & editing

Affiliation Division of Health Sciences, Department of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, Suita, Japan

https://orcid.org/0000-0002-9430-2362

⨯
[ ... ],
Tetsuo Takehara

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: takehara@gh.med.osaka-u.ac.jp

Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan

https://orcid.org/0000-0001-5036-3457

⨯
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Fucosylated haptoglobin is a novel predictive marker of hepatocellular carcinoma after hepatitis C virus elimination in patients with advanced liver fibrosis

Kumiko Shirai,
Hayato Hikita,
Ryotaro Sakamori,
Akira Doi,
Yuki Tahata,
Sadatsugu Sakane,
Yoshihiro Kamada,
Kazuhiro Murai,
Akira Nishio,
Ryoko Yamada

Published: December 21, 2022
https://doi.org/10.1371/journal.pone.0279416

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Hepatocellular carcinoma
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Albumins
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Liver fibrosis
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Hepatitis C virus
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Haptoglobins
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Fibrosis
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