Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-tolerant patients

• Laurence M. Moss,

  Roles Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Centre for Human Drug Research (CHDR), Leiden, The Netherlands, Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

  https://orcid.org/0000-0001-6182-0553

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• Marijke Hyke Algera,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

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• Robert Dobbins,

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Indivior Inc., North Chesterfield, Virginia, United States of America

  https://orcid.org/0000-0002-6069-4425

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• Frank Gray,

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Indivior Inc., North Chesterfield, Virginia, United States of America

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• Stephanie Strafford,

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Visualization, Writing – review & editing

  Affiliation Indivior Inc., North Chesterfield, Virginia, United States of America

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• Amy Heath,

  Roles Formal analysis, Resources, Software, Writing – review & editing

  Affiliation Indivior Inc., North Chesterfield, Virginia, United States of America

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• Monique van Velzen,

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

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• Jules A. A. C. Heuberger,

  Roles Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Centre for Human Drug Research (CHDR), Leiden, The Netherlands

  https://orcid.org/0000-0001-7202-5088

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• Marieke Niesters,

  Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

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• Erik Olofsen,

  Roles Conceptualization, Investigation, Methodology, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

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• Celine M. Laffont,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Software, Writing – original draft, Writing – review & editing

  Affiliation Indivior Inc., North Chesterfield, Virginia, United States of America

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• Albert Dahan,

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

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• Geert Jan Groeneveld

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: GGroeneveld@chdr.nl

  Affiliations Centre for Human Drug Research (CHDR), Leiden, The Netherlands, Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

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