About the Authors

Laurence M. Moss

Roles Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliations Centre for Human Drug Research (CHDR), Leiden, The Netherlands, Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Marijke Hyke Algera

Roles Investigation, Writing – review & editing

Affiliation Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Robert Dobbins

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Indivior Inc., North Chesterfield, Virginia, United States of America

Frank Gray

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Indivior Inc., North Chesterfield, Virginia, United States of America

Stephanie Strafford

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Visualization, Writing – review & editing

Affiliation Indivior Inc., North Chesterfield, Virginia, United States of America

Amy Heath

Roles Formal analysis, Resources, Software, Writing – review & editing

Affiliation Indivior Inc., North Chesterfield, Virginia, United States of America

Monique van Velzen

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Jules A. A. C. Heuberger

Roles Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Centre for Human Drug Research (CHDR), Leiden, The Netherlands

Marieke Niesters

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Erik Olofsen

Roles Conceptualization, Investigation, Methodology, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Celine M. Laffont

Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Software, Writing – original draft, Writing – review & editing

Affiliation Indivior Inc., North Chesterfield, Virginia, United States of America

Albert Dahan

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Geert Jan Groeneveld

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

GGroeneveld@chdr.nl

Affiliations Centre for Human Drug Research (CHDR), Leiden, The Netherlands, Department of Anesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

Competing Interests

The authors have read the journal’s policy and have the following competing interests: RD, FG, SS, AH, and CL are paid employees of Indivior Inc. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.