Dual-light photodynamic therapy administered daily provides a sustained antibacterial effect on biofilm and prevents Streptococcus mutans adaptation

• Sakari Nikinmaa,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland, Koite Health Oy, Espoo, Finland

  http://orcid.org/0000-0002-4241-9163

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• Heikki Alapulli,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland

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• Petri Auvinen,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Institute of Biotechnology, University of Helsinki, Helsinki, Finland

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• Martti Vaara,

  Roles Conceptualization, Supervision, Validation, Writing – review & editing

  Affiliations Northern Antibiotics, Espoo, Finland, Department of Bacteriology and Immunology, University of Helsinki, Medical School, Helsinki, Finland

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• Juha Rantala,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Koite Health Oy, Espoo, Finland

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• Esko Kankuri,

  Roles Writing – review & editing

  Affiliation Department of Pharmacology, University of Helsinki, Helsinki, Finland

  http://orcid.org/0000-0002-2193-8773

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• Timo Sorsa,

  Roles Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland, Department of Oral Diseases, Karolinska Institute, Huddinge, Sweden

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• Jukka Meurman,

  Roles Conceptualization, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland, Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland

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• Tommi Pätilä

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: tommi.patila@hus.fi

  Affiliations Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland, Koite Health Oy, Espoo, Finland, Department of Congenital Heart Surgery and Organ Transplantation, New Children’s Hospital, University of Helsinki, Helsinki, Finland

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