Applying univariate vs. multivariate statistics to investigate therapeutic efficacy in (pre)clinical trials: A Monte Carlo simulation study on the example of a controlled preclinical neurotrauma trial

• Hristo Todorov,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliations Faculty of Biology, Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany, Fresenius Kabi Deutschland GmbH, Oberursel, Germany

  http://orcid.org/0000-0003-2734-7701

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• Emily Searle-White,

  Roles Validation, Writing – review & editing

  Affiliation Institute of Mathematics, Johannes Gutenberg-University Mainz, Mainz, Germany

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• Susanne Gerber

  Roles Conceptualization, Supervision, Writing – review & editing

  * E-mail: sugerber@uni-mainz.de

  Affiliation Faculty of Biology, Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany

  http://orcid.org/0000-0001-9513-0729

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