Applying univariate vs. multivariate statistics to investigate therapeutic efficacy in (pre)clinical trials: A Monte Carlo simulation study on the example of a controlled preclinical neurotrauma trial

Hristo Todorov; Emily Searle-White; Susanne Gerber

doi:10.1371/journal.pone.0230798

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Peer-reviewed

Research Article

Applying univariate vs. multivariate statistics to investigate therapeutic efficacy in (pre)clinical trials: A Monte Carlo simulation study on the example of a controlled preclinical neurotrauma trial

Hristo Todorov,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliations Faculty of Biology, Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany, Fresenius Kabi Deutschland GmbH, Oberursel, Germany

http://orcid.org/0000-0003-2734-7701

⨯
Emily Searle-White,

Roles Validation, Writing – review & editing

Affiliation Institute of Mathematics, Johannes Gutenberg-University Mainz, Mainz, Germany
⨯
Susanne Gerber

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: sugerber@uni-mainz.de

Affiliation Faculty of Biology, Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany

http://orcid.org/0000-0001-9513-0729

⨯

Applying univariate vs. multivariate statistics to investigate therapeutic efficacy in (pre)clinical trials: A Monte Carlo simulation study on the example of a controlled preclinical neurotrauma trial

Hristo Todorov,
Emily Searle-White,
Susanne Gerber

Published: March 26, 2020
https://doi.org/10.1371/journal.pone.0230798

About the Authors

Hristo Todorov

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliations Faculty of Biology, Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany, Fresenius Kabi Deutschland GmbH, Oberursel, Germany

http://orcid.org/0000-0003-2734-7701

Emily Searle-White

Roles Validation, Writing – review & editing

Affiliation Institute of Mathematics, Johannes Gutenberg-University Mainz, Mainz, Germany

Susanne Gerber

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: sugerber@uni-mainz.de

Affiliation Faculty of Biology, Institute for Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany

http://orcid.org/0000-0001-9513-0729

Competing Interests

The work of HT was funded by Fresenius Kabi Deutschland GmbH. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The work of SG was partly supported by the CRC 1193.

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Simulation and modeling
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Analysis of variance
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Neurotrauma
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Monte Carlo method
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