Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model

• Jared D. Hoffman,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America, Department of Pharmacology and Nutritional Science, University of Kentucky, Lexington, Kentucky, United States of America

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• Lucille M. Yanckello,

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America, Department of Pharmacology and Nutritional Science, University of Kentucky, Lexington, Kentucky, United States of America

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• George Chlipala,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Writing – original draft, Writing – review & editing

  Affiliation Research Resources Center, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• Tyler C. Hammond,

  Roles Conceptualization, Validation, Writing – review & editing

  Affiliations Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America, Department of Neuroscience, University of Kentucky, Lexington, Kentucky, United States of America

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• Scott D. McCulloch,

  Roles Formal analysis, Investigation, Methodology, Resources, Software, Visualization, Writing – review & editing

  Affiliation Metabolon Inc., Durham, North Carolina, United States of America

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• Ishita Parikh,

  Roles Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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• Sydney Sun,

  Roles Formal analysis, Validation, Visualization, Writing – review & editing

  Affiliation Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America

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• Josh M. Morganti,

  Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America, Department of Neuroscience, University of Kentucky, Lexington, Kentucky, United States of America, Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky, United States of America

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• Stefan J. Green,

  Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Research Resources Center, University of Illinois at Chicago, Chicago, Illinois, United States of America

  http://orcid.org/0000-0003-2781-359X

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• Ai-Ling Lin

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ailing.lin@uky.edu

  Affiliations Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America, Department of Pharmacology and Nutritional Science, University of Kentucky, Lexington, Kentucky, United States of America, Department of Neuroscience, University of Kentucky, Lexington, Kentucky, United States of America, F. Joseph Halcomb III, M.D. Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, United States of America

  http://orcid.org/0000-0002-5197-2219

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