Metabolomic approach to the exploration of biomarkers associated with disease activity in rheumatoid arthritis

• Chiyomi Sasaki,

  Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliations Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, Candidate Discovery Science Labs, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

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• Tomoko Hiraishi,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

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• Takuma Oku,

  Roles Conceptualization, Investigation, Methodology, Project administration, Writing – review & editing

  Affiliations Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, Candidate Discovery Science Labs, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

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• Kenji Okuma,

  Roles Investigation, Writing – review & editing

  Affiliations Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, Candidate Discovery Science Labs, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

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• Kenichi Suzumura,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

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• Motomu Hashimoto,

  Roles Conceptualization, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

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• Hiromu Ito,

  Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

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• Ichiro Aramori,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, Candidate Discovery Science Labs, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

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• Yoshitaka Hirayama

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

  * E-mail: yoshitaka.hirayama@astellas.com

  Affiliations Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, Candidate Discovery Science Labs, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

  http://orcid.org/0000-0002-5024-7453

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