About the Authors

Chiyomi Sasaki

Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft

Affiliations Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, Candidate Discovery Science Labs, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

Tomoko Hiraishi

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

Takuma Oku

Roles Conceptualization, Investigation, Methodology, Project administration, Writing – review & editing

Affiliations Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, Candidate Discovery Science Labs, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

Kenji Okuma

Roles Investigation, Writing – review & editing

Affiliations Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, Candidate Discovery Science Labs, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

Kenichi Suzumura

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

Motomu Hashimoto

Roles Conceptualization, Investigation, Methodology, Resources, Writing – review & editing

Affiliation Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Hiromu Ito

Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Writing – review & editing

Affiliation Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Ichiro Aramori

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, Candidate Discovery Science Labs, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

Yoshitaka Hirayama

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

yoshitaka.hirayama@astellas.com

Affiliations Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan, Candidate Discovery Science Labs, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: CS, TH, TO, KO, KS, IA and YH are employees of Astellas Pharma Inc. MH received research grant and/or speaker fee from Astellas Pharma Inc, Eisai Co. Ltd., Mitsubishi Tanabe Pharma Co., and Brystol-Meyers Squibb Co., Ltd., for other unrelated work. HI received a grant from Bristol-Myers Squibb Co., Ltd., and Asahi-kasei for other unrelated work. Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University is supported by Nagahama City, Shiga, Japan and four pharmaceutical companies (Mitsubishi Tanabe Pharma Co., Chugai Pharmaceutical Co. Ltd, UCB Japan Co. Ltd, and AYUMI Pharmaceutical Co.). KURAMA cohort study is supported by grant from Daiichi Sankyo Co., Ltd. This does not alter our adherence to PLOS ONE policies on sharing data and materials.