Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye

Whitney Shatz; Philip E. Hass; Nikhil Peer; Maciej T. Paluch; Craig Blanchette; Guanghui Han; Wendy Sandoval; Ashley Morando; Kelly M. Loyet; Vladimir Bantseev; Helen Booler; Susan Crowell; Amrita Kamath; Justin M. Scheer; Robert F. Kelley

doi:10.1371/journal.pone.0218613

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Open Access

Peer-reviewed

Research Article

Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye

Whitney Shatz ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

* E-mail: Shatz.whitney@gene.com

Affiliation Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

http://orcid.org/0000-0003-2996-501X

⨯
Philip E. Hass,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America
⨯
Nikhil Peer,

Roles Formal analysis, Investigation, Methodology, Validation

Current address: Purification Development, Genentech Inc., South San Francisco, California, United States of America

Affiliation Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America
⨯
Maciej T. Paluch,

Roles Investigation, Methodology, Resources

Affiliation Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America
⨯
Craig Blanchette,

Roles Supervision, Writing – review & editing

Affiliation Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America
⨯
Guanghui Han,

Roles Formal analysis, Methodology, Software, Visualization

Current address: Mass Spectrometry Center, BGI Americas, San Jose, California, United States of America

Affiliation Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, California, United States of America

http://orcid.org/0000-0002-9893-9168

⨯
Wendy Sandoval,

Roles Formal analysis, Methodology, Resources, Software, Visualization

Affiliation Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, California, United States of America
⨯
Ashley Morando,

Roles Formal analysis, Methodology, Visualization

Affiliation Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, United States of America
⨯
Kelly M. Loyet,

Roles Data curation, Formal analysis, Methodology, Resources, Software, Supervision, Validation

Affiliation Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, United States of America

http://orcid.org/0000-0002-3733-099X

⨯
Vladimir Bantseev,

Roles Formal analysis, Investigation, Methodology, Resources

Affiliation Safety Assessment, Genentech Inc., South San Francisco, California, United States of America
⨯
Helen Booler,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources

Affiliation Safety Assessment, Genentech Inc., South San Francisco, California, United States of America
⨯
Susan Crowell,

Roles Data curation, Formal analysis, Methodology, Resources, Validation, Visualization, Writing – review & editing

Affiliation Pre-clinical and Translational Pharmacokinetics, Genentech Inc., South San Francisco, California, United States of America
⨯
Amrita Kamath,

Roles Data curation, Methodology, Resources, Supervision

Affiliation Pre-clinical and Translational Pharmacokinetics, Genentech Inc., South San Francisco, California, United States of America
⨯
Justin M. Scheer,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Current address: Antibody Engineering, Boehringer Ingelheim, Ridgefield, Connecticut, United States of America

Affiliation Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America
⨯
Robert F. Kelley

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Drug Delivery, Genentech, South San Francisco, California, United States of America
⨯

Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye

Whitney Shatz,
Philip E. Hass,
Nikhil Peer,
Maciej T. Paluch,
Craig Blanchette,
Guanghui Han,
Wendy Sandoval,
Ashley Morando,
Kelly M. Loyet,
Vladimir Bantseev

Published: June 28, 2019
https://doi.org/10.1371/journal.pone.0218613

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