About the Authors

Whitney Shatz

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

Shatz.whitney@gene.com

Affiliation Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

Philip E. Hass

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

Nikhil Peer

Roles Formal analysis, Investigation, Methodology, Validation

Current address: Purification Development, Genentech Inc., South San Francisco, California, United States of America

Affiliation Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

Maciej T. Paluch

Roles Investigation, Methodology, Resources

Affiliation Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

Craig Blanchette

Roles Supervision, Writing – review & editing

Affiliation Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

Guanghui Han

Roles Formal analysis, Methodology, Software, Visualization

Current address: Mass Spectrometry Center, BGI Americas, San Jose, California, United States of America

Affiliation Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, California, United States of America

Wendy Sandoval

Roles Formal analysis, Methodology, Resources, Software, Visualization

Affiliation Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, California, United States of America

Ashley Morando

Roles Formal analysis, Methodology, Visualization

Affiliation Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, United States of America

Kelly M. Loyet

Roles Data curation, Formal analysis, Methodology, Resources, Software, Supervision, Validation

Affiliation Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, United States of America

Vladimir Bantseev

Roles Formal analysis, Investigation, Methodology, Resources

Affiliation Safety Assessment, Genentech Inc., South San Francisco, California, United States of America

Helen Booler

Roles Data curation, Formal analysis, Investigation, Methodology, Resources

Affiliation Safety Assessment, Genentech Inc., South San Francisco, California, United States of America

Susan Crowell

Roles Data curation, Formal analysis, Methodology, Resources, Validation, Visualization, Writing – review & editing

Affiliation Pre-clinical and Translational Pharmacokinetics, Genentech Inc., South San Francisco, California, United States of America

Amrita Kamath

Roles Data curation, Methodology, Resources, Supervision

Affiliation Pre-clinical and Translational Pharmacokinetics, Genentech Inc., South San Francisco, California, United States of America

Justin M. Scheer

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Current address: Antibody Engineering, Boehringer Ingelheim, Ridgefield, Connecticut, United States of America

Affiliation Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

Robert F. Kelley

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Drug Delivery, Genentech, South San Francisco, California, United States of America

Competing Interests

The authors have read the journal's policy and have the following competing interests: W.S., P.E.H., N.P., M.T.P., C.B., W.S., A.M., K.M.L., V.B., H.B., S.C., A.K., and R.F.K. are employees of Genentech. G.H. is an employee of BGI Americas, a genome sequencing company. J.M.S. is an employee of Boeringer Ingleheim, a pharmaceutical company. However, G.H. and J.M.S. were employees of Genentech through the completion of the study. There are no patents, products in development or marketed products associated with this research to declare. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.