Identification and quantification of defective virus genomes in high throughput sequencing data using DVG-profiler, a novel post-sequence alignment processing algorithm

• Trent J. Bosma ,

  Contributed equally to this work with: Trent J. Bosma, Konstantinos Karagiannis

  Roles Formal analysis, Investigation, Software, Validation, Writing – review & editing

  Affiliation Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Konstantinos Karagiannis ,

  Contributed equally to this work with: Trent J. Bosma, Konstantinos Karagiannis

  Roles Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft

  Affiliations Department of Biochemistry and Molecular Medicine, George Washington University Medical Center, Washington, DC, United States of America, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Luis Santana-Quintero,

  Roles Software, Writing – original draft, Writing – review & editing

  Affiliation Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

  http://orcid.org/0000-0002-4290-1021

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• Natalia Ilyushina,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Division of Biotechnology Review and Research II, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

  http://orcid.org/0000-0001-8178-0472

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• Tatiana Zagorodnyaya,

  Roles Investigation

  Affiliation Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Svetlana Petrovskaya,

  Roles Investigation

  Current Address: Division of Biotechnology Review and Research II, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

  Affiliation Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Majid Laassri,

  Roles Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Raymond P. Donnelly,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliation Division of Biotechnology Review and Research II, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Steven Rubin,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Vahan Simonyan,

  Roles Conceptualization, Funding acquisition, Resources, Software, Supervision

  Current Address: Department of Bioinformatics, CRISPR Therapeutics, Cambridge, Massachusetts, United States of America

  Affiliation Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Christian J. Sauder

  Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: christian.sauder@fda.hhs.gov

  Affiliation Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

  http://orcid.org/0000-0001-5490-402X

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