Data-driven, voxel-based analysis of brain PET images: Application of PCA and LASSO methods to visualize and quantify patterns of neurodegeneration

• Ivan S. Klyuzhin ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ivansk@physics.ubc.ca

  Affiliation Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

  http://orcid.org/0000-0003-0141-7628

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• Jessie F. Fu,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada

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• Andy Hong,

  Roles Formal analysis, Investigation, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada

  http://orcid.org/0000-0001-6500-6866

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• Matthew Sacheli,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Pacific Parkinson’s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

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• Nikolay Shenkov,

  Roles Methodology, Validation, Writing – review & editing

  Affiliation Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada

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• Michele Matarazzo,

  Roles Resources, Validation, Writing – review & editing

  Affiliation Pacific Parkinson’s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

  http://orcid.org/0000-0002-2907-8667

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• Arman Rahmim,

  Roles Validation, Writing – review & editing

  Affiliation Department of Radiology, Johns Hopkins University, Baltimore, Maryland, United States of America

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• A. Jon Stoessl,

  Roles Data curation, Validation, Writing – review & editing

  Affiliation Pacific Parkinson’s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

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• Vesna Sossi

  Roles Data curation, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada

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