A kinetic investigation of interacting, stimulated T cells identifies conditions for rapid functional enhancement, minimal phenotype differentiation, and improved adoptive cell transfer tumor eradication

• Jing Zhou,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations NanoSystems Biology Cancer Center, California Institute of Technology, Pasadena, California, United States of America, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United States of America

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• Michael T. Bethune,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations NanoSystems Biology Cancer Center, California Institute of Technology, Pasadena, California, United States of America, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America

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• Natalia Malkova,

  Roles Investigation, Methodology, Writing – original draft

  Affiliation Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United States of America

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• Alexander M. Sutherland,

  Roles Formal analysis, Investigation, Methodology

  Affiliations NanoSystems Biology Cancer Center, California Institute of Technology, Pasadena, California, United States of America, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United States of America

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• Begonya Comin-Anduix,

  Roles Formal analysis, Investigation

  Affiliation David Geffen School of Medicine, the Johnson Comprehensive Cancer Center, University of California, Los Angeles, California, United States of America

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• Yapeng Su,

  Roles Investigation

  Affiliations NanoSystems Biology Cancer Center, California Institute of Technology, Pasadena, California, United States of America, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United States of America

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• David Baltimore,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliations NanoSystems Biology Cancer Center, California Institute of Technology, Pasadena, California, United States of America, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America

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• Antoni Ribas,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations NanoSystems Biology Cancer Center, California Institute of Technology, Pasadena, California, United States of America, David Geffen School of Medicine, the Johnson Comprehensive Cancer Center, University of California, Los Angeles, California, United States of America

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• James R. Heath

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: heath@caltech.edu

  Affiliations NanoSystems Biology Cancer Center, California Institute of Technology, Pasadena, California, United States of America, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United States of America

  http://orcid.org/0000-0001-5356-4385

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