Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model

Le-Xun Wang; Xiao Yang; Yuan Yue; Tian Fan; Jian Hou; Guang-Xian Chen; Meng-Ya Liang; Zhong-Kai Wu

doi:10.1371/journal.pone.0178619

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Peer-reviewed

Research Article

Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model

Le-Xun Wang ,

Contributed equally to this work with: Le-Xun Wang, Xiao Yang

Affiliations Second Department of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Assisted Circulatory Laboratory of Health Ministry, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Xiao Yang ,

Contributed equally to this work with: Le-Xun Wang, Xiao Yang

Affiliations Second Department of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Assisted Circulatory Laboratory of Health Ministry, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Yuan Yue,

Affiliations Second Department of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Assisted Circulatory Laboratory of Health Ministry, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Tian Fan,

Affiliations Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
⨯
Jian Hou,

Affiliations Second Department of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Assisted Circulatory Laboratory of Health Ministry, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Guang-Xian Chen,

Affiliations Second Department of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Assisted Circulatory Laboratory of Health Ministry, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Meng-Ya Liang,

Affiliations Second Department of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Assisted Circulatory Laboratory of Health Ministry, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Zhong-Kai Wu

* E-mail: wuzhk@mail.sysu.edu.cn

Affiliations Second Department of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Assisted Circulatory Laboratory of Health Ministry, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

http://orcid.org/0000-0003-1184-1182

⨯

Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model

Le-Xun Wang,
Xiao Yang,
Yuan Yue,
Tian Fan,
Jian Hou,
Guang-Xian Chen,
Meng-Ya Liang,
Zhong-Kai Wu

Published: June 1, 2017
https://doi.org/10.1371/journal.pone.0178619

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