In vitro and in vivo antivirus activity of an anti-programmed death-ligand 1 (PD-L1) rat-bovine chimeric antibody against bovine leukemia virus infection

Asami Nishimori; Satoru Konnai; Tomohiro Okagawa; Naoya Maekawa; Ryoyo Ikebuchi; Shinya Goto; Yamato Sajiki; Yasuhiko Suzuki; Junko Kohara; Satoshi Ogasawara; Yukinari Kato; Shiro Murata; Kazuhiko Ohashi

doi:10.1371/journal.pone.0174916

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Open Access

Peer-reviewed

Research Article

In vitro and in vivo antivirus activity of an anti-programmed death-ligand 1 (PD-L1) rat-bovine chimeric antibody against bovine leukemia virus infection

Asami Nishimori,

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Satoru Konnai ,

* E-mail: konnai@vetmed.hokudai.ac.jp

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan

http://orcid.org/0000-0002-3230-7109

⨯
Tomohiro Okagawa,

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Naoya Maekawa,

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Ryoyo Ikebuchi,

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Shinya Goto,

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Yamato Sajiki,

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Yasuhiko Suzuki,

Affiliations Division of Bioresources, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan, Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan
⨯
Junko Kohara,

Affiliation Animal Research Center, Agricultural Research Department, Hokkaido Research Organization, Shintoku, Japan
⨯
Satoshi Ogasawara,

Affiliation Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Yukinari Kato,

Affiliation Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Shiro Murata,

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯
Kazuhiko Ohashi

Affiliation Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
⨯

In vitro and in vivo antivirus activity of an anti-programmed death-ligand 1 (PD-L1) rat-bovine chimeric antibody against bovine leukemia virus infection

Asami Nishimori,
Satoru Konnai,
Tomohiro Okagawa,
Naoya Maekawa,
Ryoyo Ikebuchi,
Shinya Goto,
Yamato Sajiki,
Yasuhiko Suzuki,
Junko Kohara,
Satoshi Ogasawara

Published: April 26, 2017
https://doi.org/10.1371/journal.pone.0174916

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