Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein

• Henning Leske,

  Current address: Department of Neuro-/ Pathology, Oslo University Hospital, Sognsvannsveien 20, Oslo, Norway

  Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

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• Simone Hornemann,

  Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

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• Uli Simon Herrmann,

  Current address: Department of Pediatrics, KinderSpital Zurich, University of Zurich, Steinwiesstrasse 75, Zurich, Switzerland

  Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

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• Caihong Zhu,

  Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

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• Paolo Dametto,

  Current address: CSL Behring AG, Wankdorfstrasse 10,Bern, Switzerland

  Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

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• Bei Li,

  Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

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• Florent Laferriere,

  Affiliation Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland

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• Magdalini Polymenidou,

  Affiliation Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland

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• Pawel Pelczar,

  Current address: Centre of transgenic models, University of Basel, Mattenstrasse 22, Basel, Switzerland

  Affiliation Institute of Molecular Biology and Biophysics, ETH Zurich, Otto-Stern-Weg 5, Zurich, Switzerland

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• Regina Rose Reimann,

  Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

  http://orcid.org/0000-0002-6396-4195

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• Petra Schwarz,

  Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

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• Elisabeth Jane Rushing,

  Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

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• Kurt Wüthrich ,

  * E-mail: adriano.aguzzi@usz.ch (AA); wuthrich@mol.biol.ethz.ch, wuthrich@scripps.edu (KW)

  Affiliation Department of Integrative Structural and Computational Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, United States of America

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• Adriano Aguzzi

  * E-mail: adriano.aguzzi@usz.ch (AA); wuthrich@mol.biol.ethz.ch, wuthrich@scripps.edu (KW)

  Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

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