About the Authors

Henning Leske

Current address: Department of Neuro-/ Pathology, Oslo University Hospital, Sognsvannsveien 20, Oslo, Norway

Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

Simone Hornemann

Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

Uli Simon Herrmann

Current address: Department of Pediatrics, KinderSpital Zurich, University of Zurich, Steinwiesstrasse 75, Zurich, Switzerland

Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

Caihong Zhu

Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

Paolo Dametto

Current address: CSL Behring AG, Wankdorfstrasse 10,Bern, Switzerland

Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

Bei Li

Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

Florent Laferriere

Affiliation Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland

Magdalini Polymenidou

Affiliation Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland

Pawel Pelczar

Current address: Centre of transgenic models, University of Basel, Mattenstrasse 22, Basel, Switzerland

Affiliation Institute of Molecular Biology and Biophysics, ETH Zurich, Otto-Stern-Weg 5, Zurich, Switzerland

Regina Rose Reimann

Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

Petra Schwarz

Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

Elisabeth Jane Rushing

Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

Kurt Wüthrich

adriano.aguzzi@usz.ch (AA); wuthrich@mol.biol.ethz.ch, wuthrich@scripps.edu (KW)

Affiliation Department of Integrative Structural and Computational Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, United States of America

Adriano Aguzzi

adriano.aguzzi@usz.ch (AA); wuthrich@mol.biol.ethz.ch, wuthrich@scripps.edu (KW)

Affiliation Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: AA KW SH HL. Formal analysis: AA SH HL. Funding acquisition: AA. Investigation: HL USH CZ BL PD FL RRR PS. Project administration: AA SH HL. Resources: PP. Supervision: AA KW SH. Validation: HL. Visualization: AA KW SH USH HL. Writing – original draft: AA KW SH MP EJR HL. Writing – review & editing: AA KW SH MP EJR HL.