Normal Hematopoietic Progenitor Subsets Have Distinct Reactive Oxygen Species, BCL2 and Cell-Cycle Profiles That Are Decoupled from Maturation in Acute Myeloid Leukemia

Naeem Khan; Robert K. Hills; Steve Knapper; Lora Steadman; Ushna Qureshi; Jerrald L. Rector; Charlotte Bradbury; Nigel H. Russell; Paresh Vyas; Alan K. Burnett; David Grimwade; Paul S. Hole; Sylvie D. Freeman

doi:10.1371/journal.pone.0163291

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Open Access

Peer-reviewed

Research Article

Normal Hematopoietic Progenitor Subsets Have Distinct Reactive Oxygen Species, BCL2 and Cell-Cycle Profiles That Are Decoupled from Maturation in Acute Myeloid Leukemia

Naeem Khan ,

* E-mail: n.khan.2@bham.ac.uk

Affiliation Department of Clinical Immunology, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom

http://orcid.org/0000-0002-1433-8454

⨯
Robert K. Hills,

Affiliation Department of Haematology, Cardiff University School of Medicine, University Hospital Wales, Cardiff, United Kingdom
⨯
Steve Knapper,

Affiliation Department of Haematology, Cardiff University School of Medicine, University Hospital Wales, Cardiff, United Kingdom
⨯
Lora Steadman,

Affiliation Department of Clinical Immunology, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom
⨯
Ushna Qureshi,

Affiliation Department of Clinical Immunology, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom
⨯
Jerrald L. Rector,

Affiliation Department of Clinical Immunology, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom
⨯
Charlotte Bradbury,

Affiliation School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
⨯
Nigel H. Russell,

Affiliation Centre for Clinical Haematology, Nottingham University Hospital NHS Trust, Nottingham, United Kingdom
⨯
Paresh Vyas,

Affiliation Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⨯
Alan K. Burnett,

Affiliation Department of Haematology, Cardiff University School of Medicine, University Hospital Wales, Cardiff, United Kingdom
⨯
David Grimwade,

Affiliation Department of Medical and Molecular Genetics, King’s College London School of Medicine, Guy’s & St. Thomas’ NHS Foundation Trust, London, United Kingdom
⨯
Paul S. Hole,

Affiliation Department of Haematology, Cardiff University School of Medicine, University Hospital Wales, Cardiff, United Kingdom
⨯
Sylvie D. Freeman

Affiliation Department of Clinical Immunology, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom
⨯

Normal Hematopoietic Progenitor Subsets Have Distinct Reactive Oxygen Species, BCL2 and Cell-Cycle Profiles That Are Decoupled from Maturation in Acute Myeloid Leukemia

Naeem Khan,
Robert K. Hills,
Steve Knapper,
Lora Steadman,
Ushna Qureshi,
Jerrald L. Rector,
Charlotte Bradbury,
Nigel H. Russell,
Paresh Vyas,
Alan K. Burnett

Published: September 26, 2016
https://doi.org/10.1371/journal.pone.0163291

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Acute myeloid leukemia
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Cell staining
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