Transcriptional Bursting Explains the Noise–Versus–Mean Relationship in mRNA and Protein Levels

Roy D. Dar; Sydney M. Shaffer; Abhyudai Singh; Brandon S. Razooky; Michael L. Simpson; Arjun Raj; Leor S. Weinberger

doi:10.1371/journal.pone.0158298

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Peer-reviewed

Research Article

Transcriptional Bursting Explains the Noise–Versus–Mean Relationship in mRNA and Protein Levels

Roy D. Dar ,

* E-mail: roydar@illinois.edu

Affiliations Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
⨯
Sydney M. Shaffer,

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States of America
⨯
Abhyudai Singh,

Affiliation Department of Electrical and Computer Engineering, University of Delaware, Newark, Delaware, United States of America
⨯
Brandon S. Razooky,

Affiliation Rockefeller University, New York, New York, United States of America
⨯
Michael L. Simpson,

Affiliations Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America, Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, Knoxville, Tennessee, United States of America, Department of Materials Science and Engineering, University of Tennessee, Knoxville, Knoxville, Tennessee, United States of America
⨯
Arjun Raj,

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States of America
⨯
Leor S. Weinberger

Affiliations Gladstone Institute (Virology and Immunology), San Francisco, California, United States of America, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
⨯

Transcriptional Bursting Explains the Noise–Versus–Mean Relationship in mRNA and Protein Levels

Roy D. Dar,
Sydney M. Shaffer,
Abhyudai Singh,
Brandon S. Razooky,
Michael L. Simpson,
Arjun Raj,
Leor S. Weinberger

Published: July 28, 2016
https://doi.org/10.1371/journal.pone.0158298
See the preprint

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