Defining the Active Fraction of Daptomycin against Methicillin-Resistant Staphylococcus aureus (MRSA) Using a Pharmacokinetic and Pharmacodynamic Approach

Samira M. Garonzik; Justin R. Lenhard; Alan Forrest; Patricia N. Holden; Jϋrgen B. Bulitta; Brian T. Tsuji

doi:10.1371/journal.pone.0156131

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Peer-reviewed

Research Article

Defining the Active Fraction of Daptomycin against Methicillin-Resistant Staphylococcus aureus (MRSA) Using a Pharmacokinetic and Pharmacodynamic Approach

Samira M. Garonzik,

Current address: Bristol Myers Squibb, Jersey City, NJ, United States of America

Affiliation Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America
⨯
Justin R. Lenhard,

Affiliations Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America, New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, Buffalo, NY, United States of America
⨯
Alan Forrest,

Affiliations Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America, Department of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC, United States of America
⨯
Patricia N. Holden,

Affiliations Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America, New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, Buffalo, NY, United States of America
⨯
Jϋrgen B. Bulitta ,

¶‡ These authors are joint senior authors on this work.

Affiliations Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, United States of America
⨯
Brian T. Tsuji

* E-mail: btsuji@buffalo.edu

¶‡ These authors are joint senior authors on this work.

Affiliations Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America, New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, Buffalo, NY, United States of America
⨯

Defining the Active Fraction of Daptomycin against Methicillin-Resistant Staphylococcus aureus (MRSA) Using a Pharmacokinetic and Pharmacodynamic Approach

Samira M. Garonzik,
Justin R. Lenhard,
Alan Forrest,
Patricia N. Holden,
Jϋrgen B. Bulitta,
Brian T. Tsuji

Published: June 10, 2016
https://doi.org/10.1371/journal.pone.0156131

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