About the Authors

Samira M. Garonzik

Current address: Bristol Myers Squibb, Jersey City, NJ, United States of America

Affiliation Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America

Justin R. Lenhard

Affiliations Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America, New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, Buffalo, NY, United States of America

Alan Forrest

Affiliations Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America, Department of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC, United States of America

Patricia N. Holden

Affiliations Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America, New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, Buffalo, NY, United States of America

Jϋrgen B. Bulitta

‡ These authors are joint senior authors on this work.

Affiliations Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, United States of America

Brian T. Tsuji

btsuji@buffalo.edu

‡ These authors are joint senior authors on this work.

Affiliations Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America, New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, Buffalo, NY, United States of America

Competing Interests

The daptomycin powder used in the experiments was provided to Brian T. Tsuji by Cubist Pharmaceuticals. However, this does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products to declare.

Author Contributions

Conceived and designed the experiments: SG JB BT. Performed the experiments: SG PH. Analyzed the data: SG JB AF. Contributed reagents/materials/analysis tools: BT. Wrote the paper: SG JL.