Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth

• Balakrishnan Ganapathy,

  Affiliations Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, United States of America, Department of Pediatrics, University of Pittsburgh, and Richard King Mellon Institute for Pediatric Research and Division of Pediatric Cardiology, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, United States of America

  ⨯
• Nikitha Nandhagopal,

  Affiliations Department of Pediatrics, University of Pittsburgh, and Richard King Mellon Institute for Pediatric Research and Division of Pediatric Cardiology, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, United States of America, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, United States of America

  ⨯
• Brian D. Polizzotti,

  Affiliations Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, United States of America, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States of America

  ⨯
• David Bennett,

  Current address: PAREXEL Informatics, Billerica, MA 01821, United States of America

  Affiliation Pre-clinical MRI Core, Beth Israel Deaconess Medical Center, Boston, MA 02115, United States of America

  ⨯
• Alparslan Asan,

  Affiliations Department of Pediatrics, University of Pittsburgh, and Richard King Mellon Institute for Pediatric Research and Division of Pediatric Cardiology, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, United States of America, Interdisciplinary Biomedical Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, United States of America

  ⨯
• Yijen Wu,

  Affiliations Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, United States of America, Rangos Research Center Animal Imaging Core, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, United States of America

  ⨯
• Bernhard Kühn

  * E-mail: Bernhard.kuhn2@CHP.edu

  Affiliations Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, United States of America, Department of Pediatrics, University of Pittsburgh, and Richard King Mellon Institute for Pediatric Research and Division of Pediatric Cardiology, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, United States of America, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States of America, McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, United States of America

  ⨯