About the Authors

Balakrishnan Ganapathy

Affiliations Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, United States of America, Department of Pediatrics, University of Pittsburgh, and Richard King Mellon Institute for Pediatric Research and Division of Pediatric Cardiology, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, United States of America

Nikitha Nandhagopal

Affiliations Department of Pediatrics, University of Pittsburgh, and Richard King Mellon Institute for Pediatric Research and Division of Pediatric Cardiology, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, United States of America, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, United States of America

Brian D. Polizzotti

Affiliations Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, United States of America, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States of America

David Bennett

Current address: PAREXEL Informatics, Billerica, MA 01821, United States of America

Affiliation Pre-clinical MRI Core, Beth Israel Deaconess Medical Center, Boston, MA 02115, United States of America

Alparslan Asan

Affiliations Department of Pediatrics, University of Pittsburgh, and Richard King Mellon Institute for Pediatric Research and Division of Pediatric Cardiology, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, United States of America, Interdisciplinary Biomedical Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, United States of America

Yijen Wu

Affiliations Department of Developmental Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, United States of America, Rangos Research Center Animal Imaging Core, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, United States of America

Bernhard Kühn

Bernhard.kuhn2@CHP.edu

Affiliations Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, United States of America, Department of Pediatrics, University of Pittsburgh, and Richard King Mellon Institute for Pediatric Research and Division of Pediatric Cardiology, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, United States of America, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States of America, McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, United States of America

Competing Interests

PAREXEL Informatics provided support in the form of salary for DB. This does not alter the authors' adherence to PLOS ONE policies on data sharing and materials.

Author Contributions

Conceived and designed the experiments: BG BDP BK. Performed the experiments: BG NN BDP DB AA YW. Analyzed the data: BG NN BDP DB AA YW. Wrote the paper: BG NN BDP DB AA YW BK. MRI data obtained: DB YW. MRI data analyzed: BG NN DB YW.