Defining Disease Phenotypes in Primary Care Electronic Health Records by a Machine Learning Approach: A Case Study in Identifying Rheumatoid Arthritis

Shang-Ming Zhou; Fabiola Fernandez-Gutierrez; Jonathan Kennedy; Roxanne Cooksey; Mark Atkinson; Spiros Denaxas; Stefan Siebert; William G. Dixon; Terence W. O’Neill; Ernest Choy; Cathie Sudlow; UK Biobank Follow-up and Outcomes Group; Sinead Brophy

doi:10.1371/journal.pone.0154515

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Open Access

Peer-reviewed

Research Article

Defining Disease Phenotypes in Primary Care Electronic Health Records by a Machine Learning Approach: A Case Study in Identifying Rheumatoid Arthritis

Shang-Ming Zhou ,

* E-mail: s.zhou@swansea.ac.uk; smzhou@ieee.org

Affiliation Institute of Life Science, College of Medicine, Swansea University, Swansea, United Kingdom
⨯
Fabiola Fernandez-Gutierrez,

Affiliation Institute of Life Science, College of Medicine, Swansea University, Swansea, United Kingdom
⨯
Jonathan Kennedy,

Affiliation Institute of Life Science, College of Medicine, Swansea University, Swansea, United Kingdom
⨯
Roxanne Cooksey,

Affiliation Institute of Life Science, College of Medicine, Swansea University, Swansea, United Kingdom
⨯
Mark Atkinson,

Affiliation Institute of Life Science, College of Medicine, Swansea University, Swansea, United Kingdom
⨯
Spiros Denaxas,

Affiliation UCL Institute of Health Informatics and Farr Institute of Health Informatics Research, London, United Kingdom
⨯
Stefan Siebert,

Affiliation Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
⨯
William G. Dixon,

Affiliation Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom
⨯
Terence W. O’Neill,

Affiliation Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom
⨯
Ernest Choy,

Affiliation Arthritis Research UK CREATE Centre and Welsh Arthritis Research Network, School of Medicine, Cardiff University, Cardiff, United Kingdom
⨯
Cathie Sudlow,

Affiliation Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
UK Biobank Follow-up and Outcomes Group ,

¶The complete membership of the author group (UK Biobank Follow-up and Outcomes Group) can be found in the Acknowledgments

Affiliation The UK Biobank, Stockport, United Kingdom
⨯
Sinead Brophy

Affiliation Institute of Life Science, College of Medicine, Swansea University, Swansea, United Kingdom
⨯

Defining Disease Phenotypes in Primary Care Electronic Health Records by a Machine Learning Approach: A Case Study in Identifying Rheumatoid Arthritis

Shang-Ming Zhou,
Fabiola Fernandez-Gutierrez,
Jonathan Kennedy,
Roxanne Cooksey,
Mark Atkinson,
Spiros Denaxas,
Stefan Siebert,
William G. Dixon,
Terence W. O’Neill,
Ernest Choy

Published: May 2, 2016
https://doi.org/10.1371/journal.pone.0154515

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