Glucose Homeostatic Law: Insulin Clearance Predicts the Progression of Glucose Intolerance in Humans

• Kaoru Ohashi ,

  Contributed equally to this work with: Kaoru Ohashi, Hisako Komada

  Affiliation Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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• Hisako Komada ,

  Contributed equally to this work with: Kaoru Ohashi, Hisako Komada

  Affiliation Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan

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• Shinsuke Uda,

  Affiliation Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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• Hiroyuki Kubota,

  Affiliation Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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• Toshinao Iwaki,

  Affiliation Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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• Hiroki Fukuzawa,

  Affiliation Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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• Yasunori Komori,

  Affiliation Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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• Masashi Fujii,

  Affiliation Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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• Yu Toyoshima,

  Affiliation Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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• Kazuhiko Sakaguchi,

  Affiliation Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan

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• Wataru Ogawa ,

  * E-mail: ogawa@med.kobe-u.ac.jp (WO); skuroda@bs.s.u-tokyo.ac.jp (SK)

  Affiliation Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan

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• Shinya Kuroda

  * E-mail: ogawa@med.kobe-u.ac.jp (WO); skuroda@bs.s.u-tokyo.ac.jp (SK)

  Affiliations Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo, Japan, Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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