What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity?

Julien Philippe; Mehdi Derhourhi; Emmanuelle Durand; Emmanuel Vaillant; Aurélie Dechaume; Iandry Rabearivelo; Véronique Dhennin; Martine Vaxillaire; Franck De Graeve; Olivier Sand; Philippe Froguel; Amélie Bonnefond

doi:10.1371/journal.pone.0143373

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Open Access

Peer-reviewed

Research Article

What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity?

Julien Philippe,

Affiliations CNRS-UMR8199, Lille Pasteur Institute, Lille, France, Lille University, Lille, France, European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France
⨯
Mehdi Derhourhi,

Affiliations CNRS-UMR8199, Lille Pasteur Institute, Lille, France, Lille University, Lille, France, European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France
⨯
Emmanuelle Durand,

Affiliations CNRS-UMR8199, Lille Pasteur Institute, Lille, France, Lille University, Lille, France, European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France
⨯
Emmanuel Vaillant,

Affiliations CNRS-UMR8199, Lille Pasteur Institute, Lille, France, Lille University, Lille, France, European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France
⨯
Aurélie Dechaume,

Affiliations CNRS-UMR8199, Lille Pasteur Institute, Lille, France, Lille University, Lille, France, European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France
⨯
Iandry Rabearivelo,

Affiliations CNRS-UMR8199, Lille Pasteur Institute, Lille, France, Lille University, Lille, France, European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France
⨯
Véronique Dhennin,

Affiliations CNRS-UMR8199, Lille Pasteur Institute, Lille, France, Lille University, Lille, France, European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France
⨯
Martine Vaxillaire,

Affiliations CNRS-UMR8199, Lille Pasteur Institute, Lille, France, Lille University, Lille, France, European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France
⨯
Franck De Graeve,

Affiliations CNRS-UMR8199, Lille Pasteur Institute, Lille, France, Lille University, Lille, France, European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France
⨯
Olivier Sand,

Affiliations CNRS-UMR8199, Lille Pasteur Institute, Lille, France, Lille University, Lille, France, European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France
⨯
Philippe Froguel ,

* E-mail: froguel@good.ibl.fr (PF); amelie.bonnefond@inserm.fr (AB)

Affiliations CNRS-UMR8199, Lille Pasteur Institute, Lille, France, Lille University, Lille, France, European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France, Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Amélie Bonnefond

* E-mail: froguel@good.ibl.fr (PF); amelie.bonnefond@inserm.fr (AB)

Affiliations CNRS-UMR8199, Lille Pasteur Institute, Lille, France, Lille University, Lille, France, European Genomic Institute for Diabetes (EGID), FR 3508, Lille, France
⨯

What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity?

Julien Philippe,
Mehdi Derhourhi,
Emmanuelle Durand,
Emmanuel Vaillant,
Aurélie Dechaume,
Iandry Rabearivelo,
Véronique Dhennin,
Martine Vaxillaire,
Franck De Graeve,
Olivier Sand

Published: November 23, 2015
https://doi.org/10.1371/journal.pone.0143373

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Diabetes mellitus
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DNA sequencing
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Probe hybridization
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