Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study

Nikhil P. Krishnan; Nhu Q. Nguyen; Krisztina M. Papp-Wallace; Robert A. Bonomo; Focco van den Akker

doi:10.1371/journal.pone.0136813

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Peer-reviewed

Research Article

Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study

Nikhil P. Krishnan ,

Contributed equally to this work with: Nikhil P. Krishnan, Nhu Q. Nguyen

Affiliation Department of Biochemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, United States of America
⨯
Nhu Q. Nguyen ,

Contributed equally to this work with: Nikhil P. Krishnan, Nhu Q. Nguyen

Affiliation Department of Biochemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, United States of America
⨯
Krisztina M. Papp-Wallace,

Affiliation Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH, 44106, United States of America
⨯
Robert A. Bonomo,

Affiliations Department of Biochemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, United States of America, Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH, 44106, United States of America, Department of Medicine, Case Western Reserve University, Cleveland, OH, United States of America, Department of Pharmacology, Case Western Reserve University, Cleveland, OH, United States of America, Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, United States of America
⨯
Focco van den Akker

* E-mail: focco.vandenakker@case.edu

Affiliation Department of Biochemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, United States of America
⨯

Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study

Nikhil P. Krishnan,
Nhu Q. Nguyen,
Krisztina M. Papp-Wallace,
Robert A. Bonomo,
Focco van den Akker

Published: September 4, 2015
https://doi.org/10.1371/journal.pone.0136813

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