About the Authors

Nikhil P. Krishnan

Contributed equally to this work with: Nikhil P. Krishnan, Nhu Q. Nguyen

Affiliation Department of Biochemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, United States of America

Nhu Q. Nguyen

Contributed equally to this work with: Nikhil P. Krishnan, Nhu Q. Nguyen

Affiliation Department of Biochemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, United States of America

Krisztina M. Papp-Wallace

Affiliation Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH, 44106, United States of America

Robert A. Bonomo

Affiliations Department of Biochemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, United States of America, Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH, 44106, United States of America, Department of Medicine, Case Western Reserve University, Cleveland, OH, United States of America, Department of Pharmacology, Case Western Reserve University, Cleveland, OH, United States of America, Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, United States of America

Focco van den Akker

focco.vandenakker@case.edu

Affiliation Department of Biochemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH, 44106, United States of America

Competing Interests

The authors have the following interests. This work was supported by a research grant from AstraZeneca, who also provided the avibactam compound for the study. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: NPK NQN FVDA. Performed the experiments: NPK NQN FVDA. Analyzed the data: NPK NQN KMPW RAB FVDA. Wrote the paper: KMPW RAB FVDA.