Topical Application of Lithium Chloride on the Pulp Induces Dentin Regeneration

Kazuya Ishimoto; Satoru Hayano; Takeshi Yanagita; Hiroshi Kurosaka; Noriaki Kawanabe; Shinsuke Itoh; Mitsuaki Ono; Takuo Kuboki; Hiroshi Kamioka; Takashi Yamashiro

doi:10.1371/journal.pone.0121938

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Open Access

Peer-reviewed

Research Article

Topical Application of Lithium Chloride on the Pulp Induces Dentin Regeneration

Kazuya Ishimoto,

Affiliation Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Okayama, Japan
⨯
Satoru Hayano,

Affiliation Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Okayama, Japan
⨯
Takeshi Yanagita,

Affiliation Department of Orthodontics, Okayama University Hospital, Okayama, Japan
⨯
Hiroshi Kurosaka,

Current Address: Department of Orthodontics and Dentofacial Orthopedics, Osaka University Graduate School of Dentistry, Osaka Japan

Affiliation Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Okayama, Japan
⨯
Noriaki Kawanabe,

Affiliation Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Okayama, Japan
⨯
Shinsuke Itoh,

Current Address: Department of Orthodontics and Dentofacial Orthopedics, Osaka University Graduate School of Dentistry, Osaka Japan

Affiliation Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Okayama, Japan
⨯
Mitsuaki Ono,

Affiliation Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Okayama, Japan
⨯
Takuo Kuboki,

Affiliation Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Okayama, Japan
⨯
Hiroshi Kamioka,

Affiliation Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Okayama, Japan
⨯
Takashi Yamashiro

* E-mail: yamashiro@dent.osaka-u.ac.jp

Current Address: Department of Orthodontics and Dentofacial Orthopedics, Osaka University Graduate School of Dentistry, Osaka Japan

Affiliation Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical sciences, Okayama, Japan
⨯

Topical Application of Lithium Chloride on the Pulp Induces Dentin Regeneration

Kazuya Ishimoto,
Satoru Hayano,
Takeshi Yanagita,
Hiroshi Kurosaka,
Noriaki Kawanabe,
Shinsuke Itoh,
Mitsuaki Ono,
Takuo Kuboki,
Hiroshi Kamioka,
Takashi Yamashiro

Published: March 26, 2015
https://doi.org/10.1371/journal.pone.0121938

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Dentin
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Odontoblasts
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Teeth
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Wnt signaling cascade
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Regeneration
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Molars
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Dental pulp
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Tooth regeneration
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