Untargeted Metabolomic Analysis of Human Plasma Indicates Differentially Affected Polyamine and L-Arginine Metabolism in Mild Cognitive Impairment Subjects Converting to Alzheimer’s Disease

Stewart F. Graham; Olivier P. Chevallier; Christopher T. Elliott; Christian Hölscher; Janet Johnston; Bernadette McGuinness; Patrick G. Kehoe; Anthony Peter Passmore; Brian D. Green

doi:10.1371/journal.pone.0119452

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Open Access

Peer-reviewed

Research Article

Untargeted Metabolomic Analysis of Human Plasma Indicates Differentially Affected Polyamine and L-Arginine Metabolism in Mild Cognitive Impairment Subjects Converting to Alzheimer’s Disease

Stewart F. Graham ,

* E-mail: stewart.graham@beaumont.edu

Affiliations Advanced Asset Technology Centre, Institute for Global Food Security, Queen’s University Belfast, Stranmillis Road, Belfast, BT9 5AG, United Kingdom, William Beaumont Research Institute, 3811 W. 13 Mile Road, Royal Oak, Michigan 48073, United States of America
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Olivier P. Chevallier,

Affiliation Advanced Asset Technology Centre, Institute for Global Food Security, Queen’s University Belfast, Stranmillis Road, Belfast, BT9 5AG, United Kingdom
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Christopher T. Elliott,

Affiliation Advanced Asset Technology Centre, Institute for Global Food Security, Queen’s University Belfast, Stranmillis Road, Belfast, BT9 5AG, United Kingdom
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Christian Hölscher,

Affiliation Division of Biomedical Sciences and Life Sciences, Lancaster University, Lancaster, LA1 4YG, United Kingdom
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Janet Johnston,

Affiliation Ageing Group, Centre for Public Health, Queen's University Belfast, Belfast, BT12 6BA, United Kingdom
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Bernadette McGuinness,

Affiliation Ageing Group, Centre for Public Health, Queen's University Belfast, Belfast, BT12 6BA, United Kingdom
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Patrick G. Kehoe,

Affiliation Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, BS16 1LE, United Kingdom
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Anthony Peter Passmore,

Affiliation Ageing Group, Centre for Public Health, Queen's University Belfast, Belfast, BT12 6BA, United Kingdom
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Brian D. Green

Affiliation Advanced Asset Technology Centre, Institute for Global Food Security, Queen’s University Belfast, Stranmillis Road, Belfast, BT9 5AG, United Kingdom
⨯

Untargeted Metabolomic Analysis of Human Plasma Indicates Differentially Affected Polyamine and L-Arginine Metabolism in Mild Cognitive Impairment Subjects Converting to Alzheimer’s Disease

Stewart F. Graham,
Olivier P. Chevallier,
Christopher T. Elliott,
Christian Hölscher,
Janet Johnston,
Bernadette McGuinness,
Patrick G. Kehoe,
Anthony Peter Passmore,
Brian D. Green

Published: March 24, 2015
https://doi.org/10.1371/journal.pone.0119452

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