A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment

Ryan Mathur; Paul G. Ince; Thais Minett; Claire J. Garwood; Pamela J. Shaw; Fiona E. Matthews; Carol Brayne; Julie E. Simpson; Stephen B. Wharton; on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group

doi:10.1371/journal.pone.0118463

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Peer-reviewed

Research Article

A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment

Ryan Mathur,

Affiliation Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, England, United Kingdom
⨯
Paul G. Ince,

Affiliation Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, England, United Kingdom
⨯
Thais Minett,

Affiliation Institute of Public Health, University of Cambridge, Cambridge, England, United Kingdom
⨯
Claire J. Garwood,

Affiliation Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, England, United Kingdom
⨯
Pamela J. Shaw,

Affiliation Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, England, United Kingdom
⨯
Fiona E. Matthews,

Affiliation MRC Biostatistics Unit, Cambridge, England, United Kingdom
⨯
Carol Brayne,

Affiliation Institute of Public Health, University of Cambridge, Cambridge, England, United Kingdom
⨯
Julie E. Simpson ,

Contributed equally to this work with: Julie E. Simpson, Stephen B. Wharton

* E-mail: julie.simpson@sheffield.ac.uk

Affiliation Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, England, United Kingdom
⨯
Stephen B. Wharton ,

Contributed equally to this work with: Julie E. Simpson, Stephen B. Wharton

Affiliation Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, England, United Kingdom
⨯
on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group

¶Membership of the MRC Cognitive Function and Ageing Neuropathology Study Group are listed on the CFAS website (www.cfas.ac.uk/pages/contacts/index.html).
⨯

A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment

Ryan Mathur,
Paul G. Ince,
Thais Minett,
Claire J. Garwood,
Pamela J. Shaw,
Fiona E. Matthews,
Carol Brayne,
Julie E. Simpson,
Stephen B. Wharton,
on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group

Published: February 23, 2015
https://doi.org/10.1371/journal.pone.0118463

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Astrocytes
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Alzheimer's disease
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