Inactivation of SAM-Methyltransferase is the Mechanism of Attenuation of a Historic Louse Borne Typhus Vaccine Strain

Open Access

Peer-reviewed

Research Article

Yan Liu,

Affiliations Department of Microbiology, School of Basic Medical Science, Anhui Medical University, Hefei, Anhui, 230032, China, Department of Pathology, University of Texas Medical Branch, Galveston, Texas, 77555-0609, United States of America
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Bin Wu,

Affiliation Jiangsu Provincial Center for Diseases Control and Prevention, Nanjing, Jiangsu, China
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George Weinstock,

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63110, United States of America
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David H. Walker,

Affiliation Department of Pathology, University of Texas Medical Branch, Galveston, Texas, 77555-0609, United States of America
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Xue-jie Yu

* E-mail: xuyu@utmb.edu

Affiliations Department of Pathology, University of Texas Medical Branch, Galveston, Texas, 77555-0609, United States of America, School of Public Health, Shandong University, Jinan, Shandong, 250012, China
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Rickettsia prowazekii
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Guinea pigs
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Typhus
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Genomics
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Single nucleotide polymorphisms
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Nucleotides
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Insertion mutation
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