In Silico Design and Biological Evaluation of a Dual Specificity Kinase Inhibitor Targeting Cell Cycle Progression and Angiogenesis

• Antony M. Latham,

  Affiliation Endothelial Cell Biology Unit, School of Molecular & Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom

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• Jayakanth Kankanala,

  Affiliation School of Chemistry, University of Leeds, Leeds, LS2 9JT, United Kingdom

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• Gareth W. Fearnley,

  Affiliation Endothelial Cell Biology Unit, School of Molecular & Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom

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• Matthew C. Gage,

  Affiliation Leeds Institute of Cardiovascular & Metabolic Medicine, Faculty of Medicine & Health, University of Leeds, Leeds LS2 9JT, United Kingdom

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• Mark T. Kearney,

  Affiliation Leeds Institute of Cardiovascular & Metabolic Medicine, Faculty of Medicine & Health, University of Leeds, Leeds LS2 9JT, United Kingdom

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• Shervanthi Homer-Vanniasinkam,

  Affiliation Leeds Institute of Cardiovascular & Metabolic Medicine, Faculty of Medicine & Health, University of Leeds, Leeds LS2 9JT, United Kingdom

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• Stephen B. Wheatcroft,

  Affiliation Leeds Institute of Cardiovascular & Metabolic Medicine, Faculty of Medicine & Health, University of Leeds, Leeds LS2 9JT, United Kingdom

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• Colin W. G. Fishwick,

  Affiliation School of Chemistry, University of Leeds, Leeds, LS2 9JT, United Kingdom

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• Sreenivasan Ponnambalam

  * E-mail: s.ponnambalam@leeds.ac.uk

  Affiliation Endothelial Cell Biology Unit, School of Molecular & Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom

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