About the Authors

Antony M. Latham

Affiliation Endothelial Cell Biology Unit, School of Molecular & Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom

Jayakanth Kankanala

Affiliation School of Chemistry, University of Leeds, Leeds, LS2 9JT, United Kingdom

Gareth W. Fearnley

Affiliation Endothelial Cell Biology Unit, School of Molecular & Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom

Matthew C. Gage

Affiliation Leeds Institute of Cardiovascular & Metabolic Medicine, Faculty of Medicine & Health, University of Leeds, Leeds LS2 9JT, United Kingdom

Mark T. Kearney

Affiliation Leeds Institute of Cardiovascular & Metabolic Medicine, Faculty of Medicine & Health, University of Leeds, Leeds LS2 9JT, United Kingdom

Shervanthi Homer-Vanniasinkam

Affiliation Leeds Institute of Cardiovascular & Metabolic Medicine, Faculty of Medicine & Health, University of Leeds, Leeds LS2 9JT, United Kingdom

Stephen B. Wheatcroft

Affiliation Leeds Institute of Cardiovascular & Metabolic Medicine, Faculty of Medicine & Health, University of Leeds, Leeds LS2 9JT, United Kingdom

Colin W. G. Fishwick

Affiliation School of Chemistry, University of Leeds, Leeds, LS2 9JT, United Kingdom

Sreenivasan Ponnambalam

s.ponnambalam@leeds.ac.uk

Affiliation Endothelial Cell Biology Unit, School of Molecular & Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom

Competing Interests

Recombinant VEGFA165 was a gift from Genentech Inc. (San Francisco, USA). This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. No competing interests exist, nor does any commercial company have input into the study.

Author Contributions

Conceived and designed the experiments: AML JK GWF MCG CWGF SP. Performed the experiments: AML JK GWF MCG. Analyzed the data: AML JK GWF. Contributed reagents/materials/analysis tools: SBW MTK SHV CWGF. Wrote the paper: AML JK GWF SP.