Development of a Physiologically Based Model to Describe the Pharmacokinetics of Methylphenidate in Juvenile and Adult Humans and Nonhuman Primates

Xiaoxia Yang; Suzanne M. Morris; Jeffery M. Gearhart; Christopher D. Ruark; Merle G. Paule; William Slikker Jr; Donald R. Mattison; Benedetto Vitiello; Nathan C. Twaddle; Daniel R. Doerge; John F. Young; Jeffrey W. Fisher

doi:10.1371/journal.pone.0106101

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Open Access

Peer-reviewed

Research Article

Development of a Physiologically Based Model to Describe the Pharmacokinetics of Methylphenidate in Juvenile and Adult Humans and Nonhuman Primates

Xiaoxia Yang ,

* E-mail: xiaoxia.yang@fda.hhs.gov

Affiliation National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
Suzanne M. Morris,

Affiliation National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
Jeffery M. Gearhart,

Affiliation The Henry M. Jackson Foundation for the Advancement of Military Medicine, Wright-Patterson Air Force Base, Ohio, United States of America
⨯
Christopher D. Ruark,

Affiliation The Henry M. Jackson Foundation for the Advancement of Military Medicine, Wright-Patterson Air Force Base, Ohio, United States of America
⨯
Merle G. Paule,

Affiliation National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
William Slikker Jr,

Affiliation National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
Donald R. Mattison,

Affiliations Risk Sciences International, Ottawa, Ontario, Canada, University of Ottawa, Ottawa, Ontario, Canada
⨯
Benedetto Vitiello,

Affiliation National Institute of Mental Health, Bethesda, Maryland, United States of America
⨯
Nathan C. Twaddle,

Affiliation National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
Daniel R. Doerge,

Affiliation National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
John F. Young,

Affiliation National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯
Jeffrey W. Fisher

Affiliation National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America
⨯

Development of a Physiologically Based Model to Describe the Pharmacokinetics of Methylphenidate in Juvenile and Adult Humans and Nonhuman Primates

Xiaoxia Yang,
Suzanne M. Morris,
Jeffery M. Gearhart,
Christopher D. Ruark,
Merle G. Paule,
William Slikker Jr,
Donald R. Mattison,
Benedetto Vitiello,
Nathan C. Twaddle,
Daniel R. Doerge

Published: September 3, 2014
https://doi.org/10.1371/journal.pone.0106101

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