Treatment of Tumors with Vitamin E Suppresses Myeloid Derived Suppressor Cells and Enhances CD8+ T Cell-Mediated Antitumor Effects

Tae Heung Kang; Jayne Knoff; Wei-Hsi Yeh; Benjamin Yang; Chenguang Wang; Young Seob Kim; Tae Woo Kim; Tzyy-Choou Wu; Chien-Fu Hung

doi:10.1371/journal.pone.0103562

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Open Access

Peer-reviewed

Research Article

Treatment of Tumors with Vitamin E Suppresses Myeloid Derived Suppressor Cells and Enhances CD8+ T Cell-Mediated Antitumor Effects

Tae Heung Kang ,

* E-mail: kangiron@kku.ac.kr (THK); chung2@jhmi.edu (CFH)

Affiliation Seoul Department of Immunology, College of Medicine, Konkuk University, Chungju, South Korea
⨯
Jayne Knoff,

Affiliation Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
⨯
Wei-Hsi Yeh,

Affiliation Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
⨯
Benjamin Yang,

Affiliation Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
⨯
Chenguang Wang,

Affiliation Department of Biostatistics and Bioinformatics, Sidney Kimmel Cancer Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Young Seob Kim,

Affiliation Seoul Department of Immunology, College of Medicine, Konkuk University, Chungju, South Korea
⨯
Tae Woo Kim,

Affiliation Division of Infection and Immunology, Graduate School of Medicine, Korea University, Seoul, South Korea
⨯
Tzyy-Choou Wu,

Affiliations Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Obstetrics and Gynecology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Molecular Microbiology and Immunology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
⨯
Chien-Fu Hung

* E-mail: kangiron@kku.ac.kr (THK); chung2@jhmi.edu (CFH)

Affiliations Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
⨯

Treatment of Tumors with Vitamin E Suppresses Myeloid Derived Suppressor Cells and Enhances CD8+ T Cell-Mediated Antitumor Effects

Tae Heung Kang,
Jayne Knoff,
Wei-Hsi Yeh,
Benjamin Yang,
Chenguang Wang,
Young Seob Kim,
Tae Woo Kim,
Tzyy-Choou Wu,
Chien-Fu Hung

Published: July 29, 2014
https://doi.org/10.1371/journal.pone.0103562

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Vitamin E
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T cells
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Cancer treatment
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