High Throughput Mutagenesis for Identification of Residues Regulating Human Prostacyclin (hIP) Receptor Expression and Function

Anke Bill; Elizabeth M. Rosethorne; Toby C. Kent; Lindsay Fawcett; Lynn Burchell; Michiel T. van Diepen; Anthony Marelli; Sergey Batalov; Loren Miraglia; Anthony P. Orth; Nicole A. Renaud; Steven J. Charlton; Martin Gosling; L. Alex Gaither; Paul J. Groot-Kormelink

doi:10.1371/journal.pone.0097973

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Open Access

Peer-reviewed

Research Article

High Throughput Mutagenesis for Identification of Residues Regulating Human Prostacyclin (hIP) Receptor Expression and Function

Anke Bill ,

Contributed equally to this work with: Anke Bill, Elizabeth M. Rosethorne

Affiliation Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America
⨯
Elizabeth M. Rosethorne ,

Contributed equally to this work with: Anke Bill, Elizabeth M. Rosethorne

Affiliation Respiratory Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom
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Toby C. Kent,

Affiliation Respiratory Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom
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Lindsay Fawcett,

Affiliation Respiratory Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom
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Lynn Burchell,

Affiliation Respiratory Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom
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Michiel T. van Diepen,

Affiliation Respiratory Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom
⨯
Anthony Marelli,

Affiliation Infectious Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
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Sergey Batalov,

Affiliation Infectious Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Loren Miraglia,

Affiliation Infectious Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Anthony P. Orth,

Affiliation Infectious Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Nicole A. Renaud,

Affiliation Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America
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Steven J. Charlton,

Affiliation Respiratory Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom
⨯
Martin Gosling,

Affiliation Respiratory Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom
⨯
L. Alex Gaither,

Affiliation Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America
⨯
Paul J. Groot-Kormelink

* E-mail: paul.groot-kormelink@novartis.com

Affiliations Respiratory Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom, Musculoskeletal Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland
⨯

High Throughput Mutagenesis for Identification of Residues Regulating Human Prostacyclin (hIP) Receptor Expression and Function

Anke Bill,
Elizabeth M. Rosethorne,
Toby C. Kent,
Lindsay Fawcett,
Lynn Burchell,
Michiel T. van Diepen,
Anthony Marelli,
Sergey Batalov,
Loren Miraglia,
Anthony P. Orth

Published: June 2, 2014
https://doi.org/10.1371/journal.pone.0097973

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Hip
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Mutagenesis
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Mutation
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