B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity

Víctor González-Ruiz; Irene Pascua; Tamara Fernández-Marcelo; Pascual Ribelles; Giulia Bianchini; Vellaisamy Sridharan; Pilar Iniesta; M. Teresa Ramos; Ana I. Olives; M. Antonia Martín; J. Carlos Menéndez

doi:10.1371/journal.pone.0095998

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Peer-reviewed

Research Article

B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity

Víctor González-Ruiz,

Affiliations Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain, BIOHET (Biologically Relevant Heterocycles) group, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
⨯
Irene Pascua,

Affiliations Departamento de Bioquímica y Biología Molecular II, Facultad de Farmacia, Universidad Complutense, Madrid, Spain, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
⨯
Tamara Fernández-Marcelo,

Affiliations Departamento de Bioquímica y Biología Molecular II, Facultad de Farmacia, Universidad Complutense, Madrid, Spain, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
⨯
Pascual Ribelles,

Affiliations BIOHET (Biologically Relevant Heterocycles) group, Facultad de Farmacia, Universidad Complutense, Madrid, Spain, Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
⨯
Giulia Bianchini,

Affiliations BIOHET (Biologically Relevant Heterocycles) group, Facultad de Farmacia, Universidad Complutense, Madrid, Spain, Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
⨯
Vellaisamy Sridharan,

Affiliations Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain, Department of Chemical and Biotechnology, SASTRA University, Thanjavur, India
⨯
Pilar Iniesta,

Affiliations Departamento de Bioquímica y Biología Molecular II, Facultad de Farmacia, Universidad Complutense, Madrid, Spain, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
⨯
M. Teresa Ramos,

Affiliations BIOHET (Biologically Relevant Heterocycles) group, Facultad de Farmacia, Universidad Complutense, Madrid, Spain, Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
⨯
Ana I. Olives,

Affiliations Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain, BIOHET (Biologically Relevant Heterocycles) group, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
⨯
M. Antonia Martín,

Affiliations Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain, BIOHET (Biologically Relevant Heterocycles) group, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
⨯
J. Carlos Menéndez

* E-mail: josecm@farm.ucm.es

Affiliations BIOHET (Biologically Relevant Heterocycles) group, Facultad de Farmacia, Universidad Complutense, Madrid, Spain, Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
⨯

B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity

Víctor González-Ruiz,
Irene Pascua,
Tamara Fernández-Marcelo,
Pascual Ribelles,
Giulia Bianchini,
Vellaisamy Sridharan,
Pilar Iniesta,
M. Teresa Ramos,
Ana I. Olives,
M. Antonia Martín

Published: May 15, 2014
https://doi.org/10.1371/journal.pone.0095998

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