Efficient Generation of Myostatin (MSTN) Biallelic Mutations in Cattle Using Zinc Finger Nucleases

Junjie Luo; Zhiyuan Song; Shengli Yu; Dan Cui; Benli Wang; Fangrong Ding; Song Li; Yunping Dai; Ning Li

doi:10.1371/journal.pone.0095225

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Open Access

Peer-reviewed

Research Article

Efficient Generation of Myostatin (MSTN) Biallelic Mutations in Cattle Using Zinc Finger Nucleases

Junjie Luo ,

Contributed equally to this work with: Junjie Luo, Zhiyuan Song

Affiliation State Key Laboratory for Agrobiotechnology, College of Biological Science, China Agricultural University, Beijing, People’s Republic of China
⨯
Zhiyuan Song ,

Contributed equally to this work with: Junjie Luo, Zhiyuan Song

Affiliation State Key Laboratory for Agrobiotechnology, College of Biological Science, China Agricultural University, Beijing, People’s Republic of China
⨯
Shengli Yu,

Affiliation State Key Laboratory for Agrobiotechnology, College of Biological Science, China Agricultural University, Beijing, People’s Republic of China
⨯
Dan Cui,

Affiliation State Key Laboratory for Agrobiotechnology, College of Biological Science, China Agricultural University, Beijing, People’s Republic of China
⨯
Benli Wang,

Affiliation State Key Laboratory for Agrobiotechnology, College of Biological Science, China Agricultural University, Beijing, People’s Republic of China
⨯
Fangrong Ding,

Affiliation Beijing GeneProtein Biotechnology Co., Ltd., Beijing, People’s Republic of China
⨯
Song Li,

Affiliation Beijing GeneProtein Biotechnology Co., Ltd., Beijing, People’s Republic of China
⨯
Yunping Dai ,

* E-mail: daiyunping@sina.com (YPD); ninglcau@cau.edu.cn (NL)

Affiliations State Key Laboratory for Agrobiotechnology, College of Biological Science, China Agricultural University, Beijing, People’s Republic of China, Beijing GeneProtein Biotechnology Co., Ltd., Beijing, People’s Republic of China
⨯
Ning Li

* E-mail: daiyunping@sina.com (YPD); ninglcau@cau.edu.cn (NL)

Affiliations State Key Laboratory for Agrobiotechnology, College of Biological Science, China Agricultural University, Beijing, People’s Republic of China, College of Animal Science, Yunnan Agricultural University, Kunming, People’s Republic of China
⨯

Efficient Generation of Myostatin (MSTN) Biallelic Mutations in Cattle Using Zinc Finger Nucleases

Junjie Luo,
Zhiyuan Song,
Shengli Yu,
Dan Cui,
Benli Wang,
Fangrong Ding,
Song Li,
Yunping Dai,
Ning Li

Published: April 17, 2014
https://doi.org/10.1371/journal.pone.0095225

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Insertion mutation
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Messenger RNA
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Polymerase chain reaction
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Cattle
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