Effects of Prolonged Exposure to Hypobaric Hypoxia on Oxidative Stress, Inflammation and Gluco-Insular Regulation: The Not-So-Sweet Price for Good Regulation

• Mario Siervo,

  Affiliation Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle on Tyne, United Kingdom

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• Heather L. Riley,

  Affiliation Warwick Systems Biology Centre, University of Warwick, Coventry, United Kingdom

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• Bernadette O. Fernandez,

  Affiliations Warwick Medical School, University of Warwick, Coventry, United Kingdom, University of Southampton, Clinical & Experimental Sciences, Faculty of Medicine, Southampton General Hospital, Southampton, United Kingdom

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• Carl A. Leckstrom,

  Affiliation Warwick Medical School, University of Warwick, Coventry, United Kingdom

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• Daniel S. Martin,

  Affiliations Centre for Altitude Space and Extreme Environment Medicine, Portex Unit, UCL Institute of Child Health, London, United Kingdom, Division of Surgery and Interventional Science, University College London, Royal Free Hospital, London, United Kingdom

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• Kay Mitchell,

  Affiliations Centre for Altitude Space and Extreme Environment Medicine, Portex Unit, UCL Institute of Child Health, London, United Kingdom, University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, United Kingdom

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• Denny Z. H. Levett,

  Affiliations Centre for Altitude Space and Extreme Environment Medicine, Portex Unit, UCL Institute of Child Health, London, United Kingdom, University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, United Kingdom, Southampton NIHR Respiratory Biomedical Research Unit, Southampton, United Kingdom

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• Hugh E. Montgomery,

  Affiliation Centre for Altitude Space and Extreme Environment Medicine, Portex Unit, UCL Institute of Child Health, London, United Kingdom

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• Monty G. Mythen,

  Affiliation Centre for Altitude Space and Extreme Environment Medicine, Portex Unit, UCL Institute of Child Health, London, United Kingdom

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• Michael P. W. Grocott ,

  Contributed equally to this work with: Michael P. W. Grocott, Martin Feelisch

  Affiliations University of Southampton, Clinical & Experimental Sciences, Faculty of Medicine, Southampton General Hospital, Southampton, United Kingdom, Centre for Altitude Space and Extreme Environment Medicine, Portex Unit, UCL Institute of Child Health, London, United Kingdom, University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, United Kingdom, Southampton NIHR Respiratory Biomedical Research Unit, Southampton, United Kingdom

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• Martin Feelisch ,

  Contributed equally to this work with: Michael P. W. Grocott, Martin Feelisch

  * E-mail: m.feelisch@soton.ac.uk

  Affiliations Warwick Systems Biology Centre, University of Warwick, Coventry, United Kingdom, Warwick Medical School, University of Warwick, Coventry, United Kingdom, University of Southampton, Clinical & Experimental Sciences, Faculty of Medicine, Southampton General Hospital, Southampton, United Kingdom, Southampton NIHR Respiratory Biomedical Research Unit, Southampton, United Kingdom

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• for the Caudwell Xtreme Everest Research Group

  ¶Membership of the Caudwell Xtreme Everest Research Group is provided in the Acknowledgments.

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