The Progeroid Phenotype of Ku80 Deficiency Is Dominant over DNA-PKCS Deficiency

Erwin Reiling; Martijn E. T. Dollé; Sameh A. Youssef; Moonsook Lee; Bhawani Nagarajah; Marianne Roodbergen; Piet de With; Alain de Bruin; Jan H. Hoeijmakers; Jan Vijg; Harry van Steeg; Paul Hasty

doi:10.1371/journal.pone.0093568

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Open Access

Peer-reviewed

Research Article

The Progeroid Phenotype of Ku80 Deficiency Is Dominant over DNA-PK_CS Deficiency

Erwin Reiling,

Affiliations National Institute for Public Health and the Environment, Bilthoven, The Netherlands, Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus MC, Rotterdam, The Netherlands
⨯
Martijn E. T. Dollé,

Affiliation National Institute for Public Health and the Environment, Bilthoven, The Netherlands
⨯
Sameh A. Youssef,

Affiliation Faculty of Veterinary Medicine, Department of Pathobiology, Utrecht University, Utrecht, The Netherlands
⨯
Moonsook Lee,

Affiliation Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Bhawani Nagarajah,

Affiliation National Institute for Public Health and the Environment, Bilthoven, The Netherlands
⨯
Marianne Roodbergen,

Affiliation National Institute for Public Health and the Environment, Bilthoven, The Netherlands
⨯
Piet de With,

Affiliation National Institute for Public Health and the Environment, Bilthoven, The Netherlands
⨯
Alain de Bruin,

Affiliation Faculty of Veterinary Medicine, Department of Pathobiology, Utrecht University, Utrecht, The Netherlands
⨯
Jan H. Hoeijmakers,

Affiliation Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus MC, Rotterdam, The Netherlands
⨯
Jan Vijg,

Affiliation Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Harry van Steeg,

Affiliations National Institute for Public Health and the Environment, Bilthoven, The Netherlands, Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Paul Hasty

* E-mail: hastye@uthscsa.edu

Affiliation Department of Molecular Medicine and Institute of Biotechnology, Barshop Institute for Longevity and Aging Studies, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯

The Progeroid Phenotype of Ku80 Deficiency Is Dominant over DNA-PK_CS Deficiency

Erwin Reiling,
Martijn E. T. Dollé,
Sameh A. Youssef,
Moonsook Lee,
Bhawani Nagarajah,
Marianne Roodbergen,
Piet de With,
Alain de Bruin,
Jan H. Hoeijmakers,
Jan Vijg

Published: April 16, 2014
https://doi.org/10.1371/journal.pone.0093568

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