The Mu Opioid Receptor Promotes Opioid and Growth Factor-Induced Proliferation, Migration and Epithelial Mesenchymal Transition (EMT) in Human Lung Cancer

Frances E. Lennon; Tamara Mirzapoiazova; Bolot Mambetsariev; Valeriy A. Poroyko; Ravi Salgia; Jonathan Moss; Patrick A. Singleton

doi:10.1371/journal.pone.0091577

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Peer-reviewed

Research Article

The Mu Opioid Receptor Promotes Opioid and Growth Factor-Induced Proliferation, Migration and Epithelial Mesenchymal Transition (EMT) in Human Lung Cancer

Frances E. Lennon,

Affiliation Section of Pulmonary and Critical Care, Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Tamara Mirzapoiazova,

Affiliation Section of Pulmonary and Critical Care, Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Bolot Mambetsariev,

Affiliation Section of Pulmonary and Critical Care, Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Valeriy A. Poroyko,

Affiliation Department of Surgery, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Ravi Salgia,

Affiliation Section of Hematology/Oncology, Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Jonathan Moss,

Affiliation Department of Anesthesia and Critical Care, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Patrick A. Singleton

* E-mail: psinglet@medicine.bsd.uchicago.edu

Affiliations Section of Pulmonary and Critical Care, Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, United States of America, Department of Anesthesia and Critical Care, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯

The Mu Opioid Receptor Promotes Opioid and Growth Factor-Induced Proliferation, Migration and Epithelial Mesenchymal Transition (EMT) in Human Lung Cancer

Frances E. Lennon,
Tamara Mirzapoiazova,
Bolot Mambetsariev,
Valeriy A. Poroyko,
Ravi Salgia,
Jonathan Moss,
Patrick A. Singleton

Published: March 24, 2014
https://doi.org/10.1371/journal.pone.0091577

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Non-small cell lung cancer
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Opioids
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Growth factors
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