A Protoberberine Derivative HWY336 Selectively Inhibits MKK4 and MKK7 in Mammalian Cells: The Importance of Activation Loop on Selectivity

• Namil Kim,

  Affiliation Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea

  ⨯
• Jeongyeon Park,

  Affiliation Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea

  ⨯
• Changdev G. Gadhe,

  Affiliation Department of Bio-New Drug Development, College of Medicine, Chosun University, Gwangju, Korea

  ⨯
• Seung Joo Cho,

  Affiliations Department of Bio-New Drug Development, College of Medicine, Chosun University, Gwangju, Korea, Department of Cellular Molecular Medicine and Research Center for Resistant Cells, College of Medicine, Chosun University, Gwangju, Korea

  ⨯
• Youngjin Oh,

  Affiliation School of Electrical and Electronic Engineering, College of Engineering, Yonsei University, Seoul, Korea

  ⨯
• Donghyun Kim,

  Affiliation School of Electrical and Electronic Engineering, College of Engineering, Yonsei University, Seoul, Korea

  ⨯
• Kiwon Song

  * E-mail: bc5012@yonsei.ac.kr

  Affiliation Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea

  ⨯