Reduction of the HIV Protease Inhibitor-Induced ER Stress and Inflammatory Response by Raltegravir in Macrophages

Xiaoxuan Zhang; Risheng Cao; Runping Liu; Renping Zhao; Yi Huang; Emily C. Gurley; Phillip B. Hylemon; William M. Pandak; Guangji Wang; Luyong Zhang; Xiaokun Li; Huiping Zhou

doi:10.1371/journal.pone.0090856

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Open Access

Peer-reviewed

Research Article

Reduction of the HIV Protease Inhibitor-Induced ER Stress and Inflammatory Response by Raltegravir in Macrophages

Xiaoxuan Zhang ,

Contributed equally to this work with: Xiaoxuan Zhang, Risheng Cao

Affiliations Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R.China, Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Risheng Cao ,

Contributed equally to this work with: Xiaoxuan Zhang, Risheng Cao

Affiliation Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Runping Liu,

Affiliations Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R.China, Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Renping Zhao,

Affiliation Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R.China
⨯
Yi Huang,

Affiliations Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R.China, School of Pharmacy, Wenzhou Medical University, Wenzhou, P.R.China
⨯
Emily C. Gurley,

Affiliation Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Phillip B. Hylemon,

Affiliations Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America
⨯
William M. Pandak,

Affiliation Department of Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America
⨯
Guangji Wang ,

* E-mail: wangguangji01@gmail.com (GW); hzhou@vcu.edu (HZ)

Affiliation Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R.China
⨯
Luyong Zhang,

Affiliation Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, P.R.China
⨯
Xiaokun Li,

Affiliation School of Pharmacy, Wenzhou Medical University, Wenzhou, P.R.China
⨯
Huiping Zhou

* E-mail: wangguangji01@gmail.com (GW); hzhou@vcu.edu (HZ)

Affiliations Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America, School of Pharmacy, Wenzhou Medical University, Wenzhou, P.R.China, Department of Internal Medicine/Gastroenterology and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America
⨯

Reduction of the HIV Protease Inhibitor-Induced ER Stress and Inflammatory Response by Raltegravir in Macrophages

Xiaoxuan Zhang,
Risheng Cao,
Runping Liu,
Renping Zhao,
Yi Huang,
Emily C. Gurley,
Phillip B. Hylemon,
William M. Pandak,
Guangji Wang,
Luyong Zhang

Published: March 13, 2014
https://doi.org/10.1371/journal.pone.0090856

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